Analysis of association and linkage for the interleukin-4 and interleukin-4 receptor alpha;: regions in Swedish atopic dermatitis families

被引:9
|
作者
Söderhäll, C
Bradley, M
Kockum, I
Luthman, H
Wahlgren, CF
Nordenskjöld, M
机构
[1] Karolinska Hosp, Dept Mol Med, Karolinska Inst, SE-17176 Stockholm, Sweden
[2] Karolinska Hosp, Dept Med, Karolinska Inst, SE-17176 Stockholm, Sweden
来源
CLINICAL AND EXPERIMENTAL ALLERGY | 2002年 / 32卷 / 08期
关键词
association; atopic dermatitis; chromosome region 5q31 and 16p12; genetic linkage; IL-4; IL-4R alpha;
D O I
10.1046/j.1365-2745.2002.01452.x
中图分类号
R392 [医学免疫学];
学科分类号
100102 ;
摘要
Background Atopic dermatitis (AD) is caused by genetic and environmental factors that interact to determine disease susceptibility and severity. Several lines of evidence suggest that the IL-4 gene and the IL-4-receptor alpha (IL-4Ralpha) gene are involved in the development of atopic diseases. Objective The objective of this study was to evaluate the possible involvement of the chromosomal regions 5q31 and 16p12, which include the genes coding for the IL-4 and the IL-4Ralpha in AD. Methods We conducted linkage analysis and association studies using the microsatellite markers D16S298 and D16S403 and a single nucleotide polymorphism in the promoter region of the IL-4 gene (- 590C/T) in 406 Swedish families with at least two siblings affected with AD, in total 1514 individuals. Results and Conclusion We report linkage (P < 0.005) to the - 590C/T polymorphism in the promoter of the IL-4 gene for the semiquantitative trait severity score of AD. Neither linkage nor association was found to the IL-4Ralpha chromosomal region.
引用
收藏
页码:1199 / 1202
页数:4
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