A straightforward approach to 2-azetidinones from imines and carboxylic acids using dimethyl sulfoxide and acetic anhydride

被引：22

作者：

Zarei, Maaroof ^{[1
]}

机构：

[1] Hormozgan Univ, Coll Sci, Dept Chem, Bandar Abbas 71961, Iran

来源：

TETRAHEDRON LETTERS | 2014年 / 55卷 / 39期

基金：

美国国家科学基金会;

关键词：

2-Azetidinone; Staudinger reaction; beta-Lactam; Activated DMSO; Schiff base; Ketene; BETA-LACTAMS; ASYMMETRIC-SYNTHESIS; VILSMEIER REAGENT; CONVENIENT METHOD; BUILDING-BLOCKS; EFFICIENT; DERIVATIVES; AMINO; RING; AZETIDIN-2-ONES;

D O I：

10.1016/j.tetlet.2014.07.089

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

The direct synthesis of 2-azetidinones from imines and carboxylic acids under mild conditions is developed. Dimethyl sulfoxide (DMSO) can be activated by acetic anhydride and the resulting active species is used for the in situ generation of ketenes from carboxylic acids. This method is cheap, simple, convenient, and efficient and the products are easily isolated. (C) 2014 Elsevier Ltd. All rights reserved.

引用

页码：5354 / 5357

页数：4

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