Detection of Autoantibodies to Tumour-Associated Antigens in Sera of Patients with Systemic Autoimmunity Using a Novel Protein Microblot Array

被引：8

作者：

Canzler, U. ^{[2
]}

Bartsch, H. ^{[1
]}

Ulitzsch, S. ^{[1
]}

Kurien, B. T. ^{[3
]}

Dorri, Y. ^{[3
]}

Scofield, R. H. ^{[3
]}

Grossmann, K. ^{[1
,5
]}

Lehmann, W. ^{[5
]}

Pilarsky, C. ^{[4
]}

Denz, A. ^{[4
]}

Gruetzmann, R. ^{[4
]}

Conrad, K. ^{[1
]}

Schmitz, M. ^{[1
]}

Rieber, E. P. ^{[1
]}

Distler, W. ^{[2
]}

Bachmann, M. P. ^{[1
]}

机构：

[1] Tech Univ Dresden, Inst Immunol, D-01307 Dresden, Germany

[2] Tech Univ Dresden, Klin & Poliklin Frauenheilkunde & Geburtshilfe, D-01307 Dresden, Germany

[3] OMRF, Oklahoma City, OK USA

[4] Tech Univ Dresden, Klin & Poliklin Viszeral Thorax & Gefasschirurg, D-01307 Dresden, Germany

[5] Attomol, Lipten, Germany

来源：

SCANDINAVIAN JOURNAL OF IMMUNOLOGY | 2009年 / 69卷 / 06期

关键词：

HUMAN HEPATOCELLULAR-CARCINOMA; CHRONIC LIVER-DISEASE; BREAST-CANCER; IMMUNE-RESPONSE; LUPUS-ERYTHEMATOSUS; PANCREATIC-CANCER; CYCLIN B1; ANTIBODY; IDENTIFICATION; AUTOANTIGENS;

D O I：

10.1111/j.1365-3083.2009.02257.x

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

It is well known that sera of patients with systemic autoimmunity contain autoantibodies to nuclear antigens. It is also known that patients with systemic autoimmunity have an increased risk for the development of tumours. Interestingly, tumour patients frequently develop autoantibodies and there is a growing list of potential tumour-associated antigens. It is, however, not known whether or not patients with systemic autoimmunity also develop antibodies to tumour-associated antigens. Here we describe the development of a novel multiprotein array allowing us to screen for autoantibodies to 30 different tumour-associated antigens in parallel. Using this novel assay, we found that the frequency of autoantibodies to the selected tumour-associated antigens is increased between 2- and 14-fold in patients with systemic autoimmunity compared with an age-matched control group.

引用

页码：563 / 569

页数：7

共 41 条

[1]

Atalay C, 2005, NEOPLASMA, V52, P32

[2] Analysis of expression of an alternative La (SS-B) cDNA and localization of the encoded N- and C-terminal peptides [J].

Bachmann, M ;

Grolz, D ;

Bartsch, H ;

Klein, RR ;

Troster, H .

BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH, 1997, 1356 (01) :53-63

[3] Hodgkin's lymphoma in systemic lupus erythematosus [J].

Bernatsky, S. ;

Ramsey-Goldman, R. ;

Isenberg, D. ;

Rahman, A. ;

Dooley, M. A. ;

Sibley, J. ;

Boivin, J.-F. ;

Joseph, L. ;

Armitage, J. ;

Zoma, A. ;

Clarke, A. .

RHEUMATOLOGY, 2007, 46 (05) :830-832

[4] Truncating mutations of RB1CC1 in human breast cancer [J].

Chano, T ;

Kontani, K ;

Teramoto, K ;

Okabe, H ;

Ikegawa, S .

NATURE GENETICS, 2002, 31 (03) :285-288

[5] IMMUNITY TO ONCOGENIC PROTEINS [J].

CHEEVER, MA ;

DISIS, ML ;

BERNHARD, H ;

GRALOW, JR ;

HAND, SL ;

HUSEBY, ES ;

QIN, HL ;

TAKAHASHI, M ;

CHEN, W .

IMMUNOLOGICAL REVIEWS, 1995, 145 :33-59

[6] Diversity of antinuclear antibody responses in hepatocellular carcinoma [J].

Covini, G ;

vonMuhlen, CA ;

Pacchetti, S ;

Colombo, M ;

Chan, EKL ;

Tan, EM .

JOURNAL OF HEPATOLOGY, 1997, 26 (06) :1255-1265

[7]

Covini G, 1997, HEPATOLOGY, V25, P75

[8] DETECTION OF ANTIBODIES AGAINST THE CELLULAR PROTEIN P53 IN SERA FROM PATIENTS WITH BREAST-CANCER [J].

CRAWFORD, LV ;

PIM, DC ;

BULBROOK, RD .

INTERNATIONAL JOURNAL OF CANCER, 1982, 30 (04) :403-408

[9] High-titer HER-2/neu protein-specific antibody can be detected in patients with early-stage breast cancer [J].

Disis, ML ;

Pupa, SM ;

Gralow, JR ;

Dittadi, R ;

Menard, S ;

Cheever, MA .

JOURNAL OF CLINICAL ONCOLOGY, 1997, 15 (11) :3363-3367

[10] Autoantibodies to annexin XI-A and other autoantigens in the diagnosis of breast cancer [J].

Fernández-Madrid, F ;

Tang, NM ;

Alansari, H ;

Granda, JL ;

Tait, L ;

Amirikia, KC ;

Moroianu, M ;

Wang, XJ ;

Karvonen, RL .

CANCER RESEARCH, 2004, 64 (15) :5089-5096

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