Matrix metalloproteinase 9 is involved in airway inflammation in cough variant asthma

被引：39

作者：

Ma, Hui-Ping ^{[1
]}

Li, Wei ^{[2
]}

Liu, Xiao-Min ^{[3
]}

机构：

[1] Jining 1 Peoples Hosp, Dept Resp Med, Jining 272111, Shandong, Peoples R China

[2] Jining 1 Peoples Hosp, Dept Otorhinolaryngol, Jining 272111, Shandong, Peoples R China

[3] Harbin Med Univ, Dept Resp Med, Affiliated Hosp 1, Harbin 150001, Heilongjiang, Peoples R China

来源：

EXPERIMENTAL AND THERAPEUTIC MEDICINE | 2014年 / 8卷 / 04期

关键词：

cough variant asthma; matrix metalloproteinase 9; inflammation; MATRIX METALLOPROTEINASES; SPUTUM; DISEASE; MMP-9;

D O I：

10.3892/etm.2014.1903

中图分类号：

R-3 [医学研究方法]; R3 [基础医学];

学科分类号：

1001 ;

摘要：

Previous studies have revealed the role of matrix metalloproteinase 9 (MMP9) in asthma and chronic obstructive pulmonary disease (COPD). However, its role in airway inflammation in cough variant asthma (CVA) remains unknown. In the present study, variations in the levels of MMP9 and interleukin (IL)-5 in the induced sputum of patients with CVA prior to and following therapy with inhaled corticosteroid and long-acting beta 2-agonist (ICS/LABA), were detected. The levels of IL-5 and percentage of eosinophils (EOS) in the induced sputum from patients with CVA were significantly higher than those in the control group of healthy individuals. The levels of MMP9 in the induced sputum from patients with CVA were also significantly higher than those in the control group. Following treatment with ICS/LABA for 6-9 months, the levels of MMP9 and IL-5, as well,as the percentage of EOS, in the induced sputum from patients with CVA had significantly decreased. Thus, MMP9 may be an important biomarker in the airway inflammation of CVA.

引用

页码：1197 / 1200

页数：4

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