Application of Single-Cell Sequencing to Immunotherapy

被引：4

作者：

Beaumont, Kristin G. ^{[1
]}

Beaumont, Michael A. ^{[1
]}

Sebra, Robert ^{[1
]}

机构：

[1] Icahn Sch Med Mt Sinai, Genet & Genom Sci, 1425 Madison Ave,Box 1498, New York, NY 10029 USA

来源：

UROLOGIC CLINICS OF NORTH AMERICA | 2020年 / 47卷 / 04期

关键词：

Immunotherapy; Cancer; Single-cell analysis; Prostate cancer; Urologic cancer; Tumor heterogeneity; MULTIFOCAL PROSTATE-CANCER; GENOME-WIDE EXPRESSION; RNA-SEQ; GENE; P53; TECHNOLOGY; MUTATIONS; THERAPY; REVEALS; SPOP;

D O I：

10.1016/j.ucl.2020.07.005

中图分类号：

R5 [内科学]; R69 [泌尿科学（泌尿生殖系疾病）];

学科分类号：

1002 ; 100201 ;

摘要：

Cancer is a highly complex and heterogeneous disease and immunotherapy has shown promise as a therapeutic approach. The increased resolution afforded by single-cell analysis offers the hope of finding and characterizing previously underappreciated populations of cells that could prove useful in understanding cancer progression and treatment. Urologic and prostate cancers are inherently heterogeneous diseases, and the potential for single-cell analysis to help understand and develop immunotherapeutic approaches to treat these diseases is very exciting. In this review, we view cancer immunotherapy through a single-cell lens and discuss the state-of-the-art technologies that enable advances in this field. © 2020 Elsevier Inc.

引用

页码：475 / 485

页数：11

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