Benzimidazole: An emerging scaffold for analgesic and anti-inflammatory agents

被引：295

作者：

Gaba, Monika ^{[1
]}

Singh, Sarbjot ^{[2
]}

Mohan, Chander ^{[3
]}

机构：

[1] ASBASJSM Coll Pharm, Dept Pharmaceut Sci, Ropar, Punjab, India

[2] Panacea Biotec Pvt Ltd, Drug Discovery Res, Mohali, Punjab, India

[3] Rayat Bahra Inst Pharm, Hoshiarpur, Punjab, India

来源：

EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY | 2014年 / 76卷

关键词：

Analgesic; Benzimidazole; Cyclooxygenase-2 (COX-2) inhibitors; Non-steroidal anti-inflammatory drugs (NSAIDs); STRUCTURE-BASED DESIGN; VANILLOID RECEPTOR; BIOLOGICAL EVALUATION; HUMAN PLATELETS; PROTEIN-KINASE; FLAP INHIBITOR; CB2; AGONISTS; PART; DERIVATIVES; ANTAGONISTS;

D O I：

10.1016/j.ejmech.2014.01.030

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

Within the vast range of heterocycles, benzimidazole and its derivatives are found to be trendy structures employed for discovery of drugs in the field of pharmaceutical and medicinal chemistry. The unique structural features of benzimidazole and a wide range of biological activities of its derivatives made it privileged structure in drug discovery. Recently, benzimidazole scaffold has emerged as a pharmacophore of choice for designing analgesic and anti-inflammatory agents active on different clinically approved targets. To pave the way for future research, there is a need to collect the latest information in this promising area. In the present review we have collated published reports on this versatile core to provide an insight so that its full therapeutic potential can be utilized for the treatment of pain and inflammation. (C) 2014 Elsevier Masson SAS. All rights reserved.

引用

页码：494 / 505

页数：12

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