Analysis of 17 autoimmune disease-associated variants in type 1 diabetes identifies 6q23/TNFAIP3 as a susceptibility locus

被引：199

作者：

Fung, E. Y. M. G. ^{[1
]}

Smyth, D. J. ^{[1
]}

Howson, J. M. M. ^{[1
]}

Cooper, J. D. ^{[1
]}

Walker, N. M. ^{[1
]}

Stevens, H. ^{[1
]}

Wicker, L. S. ^{[1
]}

Todd, J. A. ^{[1
]}

机构：

[1] Univ Cambridge, Cambridge Inst Med Res, Wellcome Trust Diabet & Inflammat Lab, Juvenile Diabet Res Fdn,Dept Med Genet, Cambridge CB2 0XY, England

来源：

GENES AND IMMUNITY | 2009年 / 10卷 / 02期

基金：

英国惠康基金; 英国医学研究理事会;

关键词：

type; 1; diabetes; single nucleotide polymorphism; autoimmune disease; SYSTEMIC-LUPUS-ERYTHEMATOSUS; GENOME-WIDE ASSOCIATION; RHEUMATOID-ARTHRITIS; CELIAC-DISEASE; GENETIC-VARIANTS; RISK ALLELES; POLYMORPHISMS; ITGAM; 6Q23; METAANALYSIS;

D O I：

10.1038/gene.2008.99

中图分类号：

Q3 [遗传学];

学科分类号：

071007 ; 090102 ;

摘要：

As a result of genome-wide association studies in larger sample sets, there has been an increase in identifying genes that influence susceptibility to individual immune-mediated diseases, as well as evidence that some genes are associated with more than one disease. In this study, we tested 17 single nucleotide polymorphisms (SNP) from 16 gene regions that have been reported in several autoimmune diseases including rheumatoid arthritis (RA), systemic lupus erythematosus (SLE), multiple sclerosis (MS), ankylosing spondylitis (AS) and Crohn's disease (CD) to determine whether the variants are also associated with type 1 diabetes (T1D). In up to 8010 cases and 9733 controls we found some evidence for an association with T1D in the regions containing genes: 2q32/STAT4, 17q21/STAT3, 5p15/ERAP1 (ARTS1), 6q23/TNFAIP3 and 12q13/KIF5A/PIP4K2C with allelic P-values ranging from 3.70 x 10(-3) to 3.20 x 10(-5). These findings extend our knowledge of susceptibility locus sharing across different autoimmune diseases, and provide convincing evidence that the RA/SLE locus 6q23/TNFAIP3 is a newly identified T1D locus.

引用

页码：188 / 191

页数：4

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