Batch control system project for a pharmaceutical plant

被引：8

作者：

Holy, R ^{[1
]}

Pozivil, J ^{[1
]}

机构：

[1] Prague Inst Chem Technol, Fac Chem Engn, Dept Comp & Control Engn, CZ-16628 Prague 6, Czech Republic

来源：

ISA TRANSACTIONS | 2002年 / 41卷 / 02期

关键词：

batch plant; process model; procedural control; S88; standard; FDA validation;

D O I：

10.1016/S0019-0578(07)60084-6

中图分类号：

TP [自动化技术、计算机技术];

学科分类号：

0812 ;

摘要：

This paper describes a case study of a control system design for a batch pharmaceutical process. The ISA standard S88.01 batch control models and terminology were used as the main guidelines for the implementation. As the S88 is not a guide for how to apply the definitions/structures, etc., one of the main goals of our work was to create a methodology for decomposition of functional requirements in terms of S88 models and structures. This methodology was tested on a real problem, described in the case study. Also presented are some remarks on project methodology and Food and Drug Administration validation. (C) 2002 ISA-The Instrumentation, Systems, and Automation Society.

引用

页码：245 / 254

页数：10

共 12 条

[1] Process model and recipe structure, the conceptual design for a flexible batch plant
Bastiaan, HK
[J]. ISA TRANSACTIONS, 1997, 36 (04) : 249 - 255
[2] BUNCH M, 1998, THESIS U LEEDS
[3] *CNI, 1998, EN ISO 9000 3 QUAL 3
[4] CROWL TE, 1998, S88 01 CONCEPTS STRE
[5] Fleming D. W., 1998, S88 IMPLEMENTATION G
[6] HOLY R, 1999, P 12 INT C PROC CONT
[7] *ISA INT SOC MEAS, 1995, ANSIISAS8801 INT S 1
[8] Decomposition of requirements specifications for batch process control
Love, J
Bunch, M
[J]. CHEMICAL ENGINEERING RESEARCH & DESIGN, 1998, 76 (A8) : 973 - 979
[9] Organizing for an initial implementation of S88
Nelson, PR
Shull, RS
[J]. ISA TRANSACTIONS, 1997, 36 (03) : 189 - 195
[10] SALAZAR J, 1996, PHARM DEV TECHNOL, V20, P46

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