The Role of the Immune System in Metabolic Health and Disease

被引：225

作者：

Zmora, Niv ^{[1
,2
,3
]}

Bashiardes, Stavros ^{[1
]}

Levy, Maayan ^{[1
]}

Elinav, Eran ^{[1
]}

机构：

[1] Weizmann Inst Sci, Dept Immunol, IL-7610001 Rehovot, Israel

[2] Tel Aviv Sourasky Med Ctr, Dept Internal Med, IL-6423906 Tel Aviv, Israel

[3] Tel Aviv Univ, Res Ctr Digest Tract & Liver Dis, Tel Aviv Sourasky Med Ctr, Sackler Fac Med, IL-6423906 Tel Aviv, Israel

来源：

CELL METABOLISM | 2017年 / 25卷 / 03期

基金：

欧洲研究理事会; 以色列科学基金会;

关键词：

INDUCED INSULIN-RESISTANCE; DIET-INDUCED OBESITY; ADIPOSE-TISSUE MACROPHAGES; TUMOR-NECROSIS-FACTOR; FATTY LIVER-DISEASE; TOLL-LIKE RECEPTORS; KAPPA-B-ALPHA; GUT MICROBIOTA; PPAR-GAMMA; BREAST-MILK;

D O I：

10.1016/j.cmet.2017.02.006

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

In addition to the immune system's traditional roles of conferring anti-infectious and anti-neoplastic protection, it has been recently implicated in the regulation of systemic metabolic homeostasis. This cross-talk between the immune and the metabolic systems is pivotal in promoting "metabolic health" throughout the life of an organism and plays fundamental roles in its adaptation to ever-changing environmental makeups and nutritional availability. Perturbations in this intricate immune-metabolic cross-talk contribute to the tendency to develop altered metabolic states that may culminate in metabolic disorders such as malnutrition, obesity, type 2 diabetes mellitus (T2DM), and other features of the metabolic syndrome. Regulators of immune-metabolic interactions include host genetics, nutritional status, and the intestinal microbiome. In this Perspective, we highlight current understanding of immune-metabolism interactions, illustrate differences among individuals and between populations in this respect, and point toward future avenues of research possibly enabling immune harnessing as means of personalized treatment for common metabolic disorders.

引用

页码：506 / 521

页数：16

共 203 条

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