Sensory Deviancy Detection Measured Directly Within the Human Nucleus Accumbens

被引：14

作者：

Duerschmid, Stefan ^{[1
,3
,4
]}

Zaehle, Tino ^{[3
,4
,5
]}

Hinrichs, Hermann ^{[3
,4
,6
,7
]}

Heinze, Hans-Jochen ^{[3
,4
,6
,7
]}

Voges, Juergen ^{[5
,6
]}

Garrido, Marta I. ^{[8
,9
,10
]}

Dolan, Raymond J. ^{[11
,12
,13
]}

Knight, Robert T. ^{[1
,2
]}

机构：

[1] Univ Calif Berkeley, Helen Wills Neurosci Inst, Berkeley, CA 94720 USA

[2] Univ Calif Berkeley, Dept Psychol, 3210 Tolman Hall, Berkeley, CA 94720 USA

[3] Leibniz Inst Neurobiol, Dept Behav Neurol, Magdeburg, Germany

[4] Univ Magdeburg, Dept Neurol, D-39106 Magdeburg, Germany

[5] Univ Magdeburg, Dept Stereotact Neurosurg, D-39106 Magdeburg, Germany

[6] German Ctr Neurodegenerat Dis DZNE, Magdeburg, Germany

[7] Univ Queensland, Forschungscampus STIMULATE, Brisbane, Qld 4072, Australia

[8] Univ Queensland, Queensland Brain Inst, Brisbane, Qld 4072, Australia

[9] Univ Queensland, Ctr Adv Imaging, Brisbane, Qld 4072, Australia

[10] Univ Queensland, Australian Res Council Ctr Excellence Integrat Br, Brisbane, Qld 4072, Australia

[11] UCL, Wellcome Trust Ctr Neuroimaging, London, England

[12] Humboldt Univ, D-10099 Berlin, Germany

[13] Max Planck UCL Ctr Computat Psychiat & Ageing Res, London, England

来源：

CEREBRAL CORTEX | 2016年 / 26卷 / 03期

基金：

英国惠康基金; 澳大利亚研究理事会;

关键词：

auditory mismatch; P3; prediction error; predictive coding; nucleus accumbens; saliency; EVENT-RELATED POTENTIALS; NOVELTY DETECTION; STIMULI; CORTEX; MEMORY; P300; INFORMATION; REWARD; RATS; P3A;

D O I：

10.1093/cercor/bhu304

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

Rapid changes in the environment evoke a comparison between expectancy and actual outcome to inform optimal subsequent behavior. The nucleus accumbens (NAcc), a key interface between the hippocampus and neocortical regions, is a candidate region for mediating this comparison. Here, we report event-related potentials obtained from the NAcc using direct intracranial recordings in 5 human participants while they listened to trains of auditory stimuli differing in their degree of deviation from repetitive background stimuli. NAcc recordings revealed an early mismatch signal (50-220 ms) in response to all deviants. NAcc activity in this time window was also sensitive to the statistics of stimulus deviancy, with larger amplitudes as a function of the level of deviancy. Importantly, this NAcc mismatch signal also predicted generation of longer latency scalp potentials (300-400 ms). The results provide direct human evidence that the NAcc is a key component of a network engaged in encoding statistics of the sensory environmental.

引用

页码：1168 / 1175

页数：8

共 31 条

[1] Prediction error as a linear function of reward probability is coded in human nucleus accumbens [J].