Inflamm-aging: STAT3 Signaling Pushes Muscle Stem Cells off Balance

被引：19

作者：

Chazaud, Benedicte ^{[1
]}

Mouchiroud, Guy ^{[1
]}

机构：

[1] Univ Lyon 1, CNRS, UMR5534, Ctr Genet & Mol & Cellular Physiol, F-69100 Villeurbanne, France

来源：

CELL STEM CELL | 2014年 / 15卷 / 04期

关键词：

SATELLITE CELL; REGENERATION; NICHE;

D O I：

10.1016/j.stem.2014.09.010

中图分类号：

Q813 [细胞工程];

学科分类号：

摘要：

Two recent studies shed light on mechanisms underlying muscle dysfunction in age and disease. They reveal that JAK-STAT signaling regulates myogenic differentiation, leading to a reduced reservoir of muscle stem cells. Both genetic and pharmacologic inhibition of STAT3 signaling improve stem cell homeostasis and physiology of aged and dystrophic muscles.

引用

页码：401 / 402

页数：2

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