Multiple FLC haplotypes defined by independent cis-regulatory variation underpin life history diversity in Arabidopsis thaliana

被引：103

作者：

Li, Peijin ^{[1
]}

Filiault, Daniele ^{[2
]}

Box, Mathew S. ^{[1
]}

Kerdaffrec, Envel ^{[2
]}

van Oosterhout, Cock ^{[3
]}

Wilczek, Amity M. ^{[4
]}

Schmitt, Johanna ^{[5
]}

McMullan, Mark ^{[3
]}

Bergelson, Joy ^{[6
]}

Nordborg, Magnus ^{[2
]}

Dean, Caroline ^{[1
]}

机构：

[1] John Innes Ctr Plant Sci Res, Norwich NR4 7UH, Norfolk, England

[2] Austrian Acad Sci, Gregor Mendel Inst, A-1030 Vienna, Austria

[3] Univ E Anglia, Dept Environm Sci, Norwich NR4 7TJ, Norfolk, England

[4] Deep Spring Coll, Big Pine, CA 93513 USA

[5] Univ Calif Davis, Davis, CA 95616 USA

[6] Univ Chicago, Dept Ecol & Evolut, Chicago, IL 60637 USA

来源：

GENES & DEVELOPMENT | 2014年 / 28卷 / 15期

基金：

美国国家科学基金会; 欧洲研究理事会; 英国生物技术与生命科学研究理事会;

关键词：

allelic heterogeneity; FLOWERING LOCUS C; noncoding polymorphism; vernalization; adaptation; FLOWERING-LOCUS-C; NATURAL VARIATION; QUANTITATIVE TRAITS; LATITUDINAL CLINE; LOCAL ADAPTATION; TIME; VERNALIZATION; BRASSICACEAE; FRIGIDA; MODEL;

D O I：

10.1101/gad.245993.114

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

Relating molecular variation to phenotypic diversity is a central goal in evolutionary biology. In Arabidopsis thaliana, FLOWERING LOCUS C (FLC) is a major determinant of variation in vernalization-the acceleration of flowering by prolonged cold. Here, through analysis of 1307 A. thaliana accessions, we identify five predominant FLC haplotypes defined by noncoding sequence variation. Genetic and transgenic experiments show that they are functionally distinct, varying in FLC expression level and rate of epigenetic silencing. Allelic heterogeneity at this single locus accounts for a large proportion of natural variation in vernalization that contributes to adaptation of A. thaliana.

引用

页码：1635 / 1640

页数：6

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