Hepatic triacylglycerol accumulation and insulin resistance

被引：208

作者：

Nagle, Cynthia A. ^{[1
]}

Klett, Eric L. ^{[1
]}

Coleman, Rosalind A. ^{[1
]}

机构：

[1] Univ N Carolina, Dept Nutr, Chapel Hill, NC 27599 USA

来源：

JOURNAL OF LIPID RESEARCH | 2009年 / 50卷

基金：

美国国家卫生研究院;

关键词：

Hepatic steatosis; diacylglycerol; phosphatidic acid; lysophosphatidic acid; ceramide; HIGH-FAT-DIET; LOW-DENSITY LIPOPROTEIN; MITOCHONDRIAL GLYCEROL-3-PHOSPHATE ACYLTRANSFERASE-1; COA DEHYDROGENASE-DEFICIENCY; ELEMENT-BINDING PROTEIN; ALPHA PPAR-ALPHA; LIVER-DISEASE; ACID OXIDATION; OB/OB MICE; OBESE MICE;

D O I：

10.1194/jlr.R800053-JLR200

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

The association of hepatic steatosis with hepatic insulin resistance and type 2 diabetes has prompted investigators to elucidate the underlying mechanism. In this review we focus on pathways of lipid metabolism, and we review recent data, primarily from mouse models, that link lipid intermediates with insulin resistance. Most of the studies that implicate acyl-CoA, lysophosphatidic acid, phosphatidic acid, diacylglycerol, or ceramide rely on indirect associations.jlr Convincing data to support the hypothesis that specific lipid intermediates initiate pathways that alter insulin signaling will require studies in which the concentration of each purported signaling molecule can be manipulated independently.-Nagle, C. A., E. L. Klett, and R. A. Coleman. Hepatic triacylglycerol accumulation and insulin resistance. J. Lipid Res. 2009. S74-S79.

引用

页码：S74 / S79

页数：6

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