Molecular cloning of human GRB-7 co-amplified with CAB1 and c-ERBB-2 in primary gastric cancer

被引：42
作者：
Kishi, T
Sasaki, H
Akiyama, N
Ishizuka, T
Sakamoto, H
Aizawa, S
Sugimura, T
Terada, M
机构：
[1] NATL CANC CTR,RES INST,DIV GENET,CHUO KU,TOKYO 104,JAPAN
[2] JIKEI UNIV,SCH MED,DEPT PATHOL 2,MINATO KU,TOKYO 105,JAPAN
来源：
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS | 1997年 / 232卷 / 01期
关键词：
D O I：
10.1006/bbrc.1997.6218
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
Many amplified-chromosome regions in human cancers have been identified, while there are only a limited number of reports for amplified genes in a single amplicon. We recently isolated four cDNA clones, A39, B47, C51, and CAB1, from 500 kilobases of yeast artificial chromosome DNA containing the c-ERBB-2 gene. B47 consisted of 615 base pairs and had about 85% homology with the corresponding sequence of mouse Grb-7. We report here the structure of human GRB-7 cDNA, and we report that the amounts of mRNA for c-ERBB-2, CAB1, and GRB-7 were elevated in concordance with the amplification. (C) 1997 Academic Press.
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页码：5 / 9
页数：5
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