Novel γ-cyclodextrin-metal-organic frameworks for encapsulation of curcumin with improved loading capacity, physicochemical stability and controlled release properties

被引：104

作者：

Chen, Yulu ^{[1
]}

Tai, Kedong ^{[1
]}

Ma, Peihua ^{[1
]}

Su, Jiaqi ^{[1
]}

Dong, Wenxia ^{[1
]}

Gao, Yanxiang ^{[1
]}

Mao, Like ^{[1
]}

Liu, Jinfang ^{[1
]}

Yuan, Fang ^{[1
]}

机构：

[1] China Agr Univ, Coll Food Sci & Nutr Engn, Key Lab Funct Dairy,Minist Educ, Key Lab Precis Nutr & Food Qual, Beijing 100083, Peoples R China

来源：

FOOD CHEMISTRY | 2021年 / 347卷

基金：

国家重点研发计划;

关键词：

CD-MOFs; gamma-Cyclodextrin; Curcumin; Stability; Controlled release; BETA-CYCLODEXTRIN; CD-MOF; INCLUSION COMPLEX; PROSTATE-CANCER; SOLUBILITY; DELIVERY; RAMAN;

D O I：

10.1016/j.foodchem.2020.128978

中图分类号：

O69 [应用化学];

学科分类号：

081704 ;

摘要：

A safe and biodegradable gamma-cyclodextrin-metal-organic-frameworks (gamma-CD-MOFs) was successfully synthesized by using an improved hydrothermal method. In this study, curcumin (Cur) was chosen for testing the encapsulation stability and release performance of gamma-CD-MOFs. Results of the crystal structure measurement indicated that the encapsulated curcumin within gamma-CD-MOFs via van der Waals forces, hydrophobic interactions and hydrogen bonding was failed to disturb the inherent microtopography and crystallinity of gamma-CD-MOFs. Compared to individual gamma-CD, the gamma-CD-MOFs exhibited improved loading capacity, physicochemical stability as well as controlled-release property in simulated digestion, and hence can be regarded as effective carriers for curcumin. Curcumin-loaded gamma-CD-MOFs with a Cur : gamma-CD-MOFs mass ratio of 2:3 (Cur-CD-MOFs/3), which showed the highest encapsulation efficiency (67.31 +/- 2.25%), improved physicochemical stability and controlled-release performance, was selected for further research and industrialization. Our results demonstrate that gamma-CD-MOFs can be regarded as a promising novel carrier for the delivery of curcumin or other hydrophobic nutraceuticals.

引用

页数：10

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