Neonatal sepsis remains one of the most important causes of death and co-morbidity in very-low-birth-weight (VLBW) infants. The aim of this study was to determine the current incidences of early-onset sepsis (EOS) and late-onset sepsis (LOS), the distribution of pathogens, and the impact of infection on co-morbidities in VLBW infants. We analyzed the data including sepsis episode from 2,386 VLBW infants enrolled in Korean Neonatal Network from January 2013 to June 2014. We defined EOS as a positive blood culture occurring between birth and 7 days of life and LOS after 7 days of life. Sepsis was found in 21.1% of VLBW infants. The risk of sepsis was inversely related to birth weight and gestational age. EOS was found in only 3.6% of VLBW infants, however the mortality rate was as high as 34.1%. EOS was associated with the increased odds for bronchopulmonary dysplasia and intraventricular hemorrhage. The vast majority of EOS was caused by Gram-positive organisms, particularly coagulase-negative staphylococci (30.6%). LOS developed in 19.4% of VLBW infants with a 16.1% mortality rate. Pathogens in LOS were dominated by coagulase-negative staphylococci (38.3%). Twenty-five percent and fifty percent of first LOS episode occurred after 12 days and 20 days from birth, respectively. Younger and smaller VLBW infants showed the earlier occurrence day for the 25% of first LOS episode. This study provides a recent nationwide epidemiology of sepsis in VLBW infants in Korea. Based on this study, successful strategies to reduce infections would improve survival and reduce morbidity.
机构:
Univ Calgary, Dept Community Hlth Sci, Fac Med, Calgary, AB T2N 2T9, Canada
Univ Calgary, Dept Pediat, Calgary, AB T2N 2T9, CanadaUniv Calgary, Dept Community Hlth Sci, Fac Med, Calgary, AB T2N 2T9, Canada
Alshaikh, B.
;
论文数: 引用数:
h-index:
机构:
Yusuf, K.
;
Sauve, R.
论文数: 0引用数: 0
h-index: 0
机构:
Univ Calgary, Dept Community Hlth Sci, Fac Med, Calgary, AB T2N 2T9, Canada
Univ Calgary, Dept Pediat, Calgary, AB T2N 2T9, CanadaUniv Calgary, Dept Community Hlth Sci, Fac Med, Calgary, AB T2N 2T9, Canada
机构:
Schneider Childrens Med Ctr Israel, Dept Neonatal Intens Care, IL-49202 Petah Tiqwa, Israel
Tel Aviv Univ, Sackler Sch Med, IL-69978 Tel Aviv, IsraelSchneider Childrens Med Ctr Israel, Dept Neonatal Intens Care, IL-49202 Petah Tiqwa, Israel
Klinger, Gil
;
Levy, Itzhak
论文数: 0引用数: 0
h-index: 0
机构:
Schneider Childrens Med Ctr Israel, Infect Dis Unit, IL-49202 Petah Tiqwa, Israel
Tel Aviv Univ, Sackler Sch Med, IL-69978 Tel Aviv, IsraelSchneider Childrens Med Ctr Israel, Dept Neonatal Intens Care, IL-49202 Petah Tiqwa, Israel
Levy, Itzhak
;
Sirota, Lea
论文数: 0引用数: 0
h-index: 0
机构:
Schneider Childrens Med Ctr Israel, Dept Neonatal Intens Care, IL-49202 Petah Tiqwa, Israel
Tel Aviv Univ, Sackler Sch Med, IL-69978 Tel Aviv, IsraelSchneider Childrens Med Ctr Israel, Dept Neonatal Intens Care, IL-49202 Petah Tiqwa, Israel
Sirota, Lea
;
Boyko, Valentina
论文数: 0引用数: 0
h-index: 0
机构:
Chaim Sheba Med Ctr, Womens & Childrens Hlth Res Unit, IL-52621 Tel Hashomer, Israel
Chaim Sheba Med Ctr, Gertner Inst, IL-52621 Tel Hashomer, IsraelSchneider Childrens Med Ctr Israel, Dept Neonatal Intens Care, IL-49202 Petah Tiqwa, Israel
Boyko, Valentina
;
Lerner-Geva, Liat
论文数: 0引用数: 0
h-index: 0
机构:
Chaim Sheba Med Ctr, Womens & Childrens Hlth Res Unit, IL-52621 Tel Hashomer, Israel
Chaim Sheba Med Ctr, Gertner Inst, IL-52621 Tel Hashomer, Israel
Tel Aviv Univ, Sackler Sch Med, IL-69978 Tel Aviv, IsraelSchneider Childrens Med Ctr Israel, Dept Neonatal Intens Care, IL-49202 Petah Tiqwa, Israel
Lerner-Geva, Liat
;
Reichman, Brian
论文数: 0引用数: 0
h-index: 0
机构:
Chaim Sheba Med Ctr, Womens & Childrens Hlth Res Unit, IL-52621 Tel Hashomer, Israel
Chaim Sheba Med Ctr, Gertner Inst, IL-52621 Tel Hashomer, Israel
Tel Aviv Univ, Sackler Sch Med, IL-69978 Tel Aviv, IsraelSchneider Childrens Med Ctr Israel, Dept Neonatal Intens Care, IL-49202 Petah Tiqwa, Israel
机构:
Univ Calgary, Dept Community Hlth Sci, Fac Med, Calgary, AB T2N 2T9, Canada
Univ Calgary, Dept Pediat, Calgary, AB T2N 2T9, CanadaUniv Calgary, Dept Community Hlth Sci, Fac Med, Calgary, AB T2N 2T9, Canada
Alshaikh, B.
;
论文数: 引用数:
h-index:
机构:
Yusuf, K.
;
Sauve, R.
论文数: 0引用数: 0
h-index: 0
机构:
Univ Calgary, Dept Community Hlth Sci, Fac Med, Calgary, AB T2N 2T9, Canada
Univ Calgary, Dept Pediat, Calgary, AB T2N 2T9, CanadaUniv Calgary, Dept Community Hlth Sci, Fac Med, Calgary, AB T2N 2T9, Canada
机构:
Schneider Childrens Med Ctr Israel, Dept Neonatal Intens Care, IL-49202 Petah Tiqwa, Israel
Tel Aviv Univ, Sackler Sch Med, IL-69978 Tel Aviv, IsraelSchneider Childrens Med Ctr Israel, Dept Neonatal Intens Care, IL-49202 Petah Tiqwa, Israel
Klinger, Gil
;
Levy, Itzhak
论文数: 0引用数: 0
h-index: 0
机构:
Schneider Childrens Med Ctr Israel, Infect Dis Unit, IL-49202 Petah Tiqwa, Israel
Tel Aviv Univ, Sackler Sch Med, IL-69978 Tel Aviv, IsraelSchneider Childrens Med Ctr Israel, Dept Neonatal Intens Care, IL-49202 Petah Tiqwa, Israel
Levy, Itzhak
;
Sirota, Lea
论文数: 0引用数: 0
h-index: 0
机构:
Schneider Childrens Med Ctr Israel, Dept Neonatal Intens Care, IL-49202 Petah Tiqwa, Israel
Tel Aviv Univ, Sackler Sch Med, IL-69978 Tel Aviv, IsraelSchneider Childrens Med Ctr Israel, Dept Neonatal Intens Care, IL-49202 Petah Tiqwa, Israel
Sirota, Lea
;
Boyko, Valentina
论文数: 0引用数: 0
h-index: 0
机构:
Chaim Sheba Med Ctr, Womens & Childrens Hlth Res Unit, IL-52621 Tel Hashomer, Israel
Chaim Sheba Med Ctr, Gertner Inst, IL-52621 Tel Hashomer, IsraelSchneider Childrens Med Ctr Israel, Dept Neonatal Intens Care, IL-49202 Petah Tiqwa, Israel
Boyko, Valentina
;
Lerner-Geva, Liat
论文数: 0引用数: 0
h-index: 0
机构:
Chaim Sheba Med Ctr, Womens & Childrens Hlth Res Unit, IL-52621 Tel Hashomer, Israel
Chaim Sheba Med Ctr, Gertner Inst, IL-52621 Tel Hashomer, Israel
Tel Aviv Univ, Sackler Sch Med, IL-69978 Tel Aviv, IsraelSchneider Childrens Med Ctr Israel, Dept Neonatal Intens Care, IL-49202 Petah Tiqwa, Israel
Lerner-Geva, Liat
;
Reichman, Brian
论文数: 0引用数: 0
h-index: 0
机构:
Chaim Sheba Med Ctr, Womens & Childrens Hlth Res Unit, IL-52621 Tel Hashomer, Israel
Chaim Sheba Med Ctr, Gertner Inst, IL-52621 Tel Hashomer, Israel
Tel Aviv Univ, Sackler Sch Med, IL-69978 Tel Aviv, IsraelSchneider Childrens Med Ctr Israel, Dept Neonatal Intens Care, IL-49202 Petah Tiqwa, Israel