A comparison of neutral Mg2+-selective ionophores in solvent polymeric membranes:: Complex stoichiometry and lipophilicity

被引：63

作者：

Zhang, W ^{[1
]}

Jenny, L ^{[1
]}

Spichiger, UE ^{[1
]}

机构：

[1] Swiss Fed Inst Technol, ETHZ, Dept Pharm, Ctr Chem Sensors Biosensors & BioAnalyt Chem, CH-8005 Zurich, Switzerland

来源：

ANALYTICAL SCIENCES | 2000年 / 16卷 / 01期

关键词：

D O I：

10.2116/analsci.16.11

中图分类号：

O65 [分析化学];

学科分类号：

070302 ; 081704 ;

摘要：

Monopodal and oligopodal Mg2+-selective ionophores were characterized by their selectivity coefficients (Separate Solution Method, SSM) in plasticized poly(vinyl chloride) (PVC) membranes. Based on a theoretical model published earlier, the stoichiometry of the Mg2+-ligand complexes was estimated while referring to the optimum molar ratio of anionic sites relative to ionophore. The sensitivity of malondiamide substituted azacrown compounds to the varying lipophilicity of the plasticizer, and to the addition of anionic sites was compared with malondiamide derivatives attached to a benzene core. In addition, the lipophilicity of these ligands was determined. In conclusion, the two classes of ionophores were rated concerning their use in human blood and urine specimens.

引用

页码：11 / 18

页数：8

共 31 条

[1] Determination of unbiased selectivity coefficients of neutral carrier-based cation-selective electrodes [J].