Synthesis of (Z)-1,3-diaryl-2-(4-aryl-1H-1,2,3-triazol-1-yl)prop-2-en-1-ones and their antibacterial studies

被引：11

作者：

Suresh, Rajendran ^{[1
]}

Muthusubramanian, Shanmugam ^{[1
]}

Paul, Nidhin ^{[1
]}

Kalidhasan, Nagarajan ^{[2
]}

Shanmugaiah, Vellasamy ^{[2
]}

机构：

[1] Madurai Kamaraj Univ, Sch Chem, Dept Organ Chem, Madurai 625021, Tamil Nadu, India

[2] Madurai Kamaraj Univ, Sch Biol Sci, Madurai 625021, Tamil Nadu, India

来源：

MEDICINAL CHEMISTRY RESEARCH | 2014年 / 23卷 / 10期

关键词：

Triazole; Microwave irradiation; 2-Propen-1-one; Regioselective synthesis; Antibacterial activity; CYCLOADDITION; AZIDES; PROTEASE;

D O I：

10.1007/s00044-014-1004-2

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

The cyclization of 1,3-diaryl-2-azido-2-propen-1-ones with various alkynes in the presence of a catalytic amount of copper sulfate-sodium ascorbate in DMSO-water mixture under microwave irradiation led to the formation of (Z)-1,3-diaryl-2-(4-substituted-1H-1,2,3-triazol-1-yl)prop-2-en-1-ones. The structure and stereochemistry of the products have been elucidated by spectroscopic and single crystal X-ray analyses. All the newly synthesized compounds have been tested for their antibacterial activity against four strains of bacteria and found to have moderate to good inhibition.

引用

页码：4367 / 4375

页数：9

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