Recent advances in developing vaccines against Toxoplasma gondii: an update

被引：45

作者：

Zhang, Nian-Zhang ^{[1
]}

Wang, Meng ^{[1
]}

Xu, Ying ^{[1
,2
]}

Petersen, Eskild ^{[3
]}

Zhu, Xing-Quan ^{[1
]}

机构：

[1] Chinese Acad Agr Sci, Lanzhou Vet Res Inst, Key Lab Vet Parasitol Gansu Prov, State Key Lab Vet Etiol Biol, Lanzhou, Peoples R China

[2] China Agr Univ, Coll Vet Med, Natl Anim Protozoa Lab, Key Lab Anim Epidemiol & Zoonosis,Minist Agr, Beijing 100094, Peoples R China

[3] Aarhus Univ, Fac Hlth Sci, Inst Clin, Dept Infect Dis, Aarhus, Denmark

来源：

EXPERT REVIEW OF VACCINES | 2015年 / 14卷 / 12期

基金：

中国国家自然科学基金;

关键词：

adjuvant; delivery system; Toxoplasma gondii; toxoplasmosis; vaccines; vaccine candidates; EXCRETORY-SECRETORY ANTIGENS; LASTING PROTECTIVE IMMUNITY; DNA VACCINE; BALB/C MICE; IFN-GAMMA; INTRANASAL IMMUNIZATION; SEQUENCE VARIATION; RHOPTRY PROTEINS; CYCLOPHILIN GENE; HOST-RESISTANCE;

D O I：

10.1586/14760584.2015.1098539

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Toxoplasma gondii, a significant public health risk, is able to infect almost all warm-blooded animals including humans, and it results in economic losses in production animals. In the last three years, a large number of vaccination experiments have been performed to control T. gondii infection, with the target of limiting the acute infection and reducing or eliminating tissue cysts in the intermediate hosts. In this paper, we summarize the latest results of the veterinary vaccines against T. gondii infection since 2013. Immunization with live-attenuated whole organisms of non-reverting mutants has been shown to induce remarkably potent immune responses associated with control of acute and chronic toxoplasmosis. The non-cyst-forming mutants are promising new tools for the development of veterinary vaccines against T. gondii infection.

引用

页码：1609 / 1621

页数：13

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