Emerging Roles of C-Myc in Cancer Stem Cell-Related Signaling and Resistance to Cancer Chemotherapy: A Potential Therapeutic Target Against Colorectal Cancer

被引：182
作者：
Elbadawy, Mohamed [1 ,2 ]
Usui, Tatsuya [1 ]
Yamawaki, Hideyuki [3 ]
Sasaki, Kazuaki [1 ]
机构：
[1] Tokyo Univ Agr & Technol, Fac Agr, Dept Vet Med, Lab Vet Pharmacol, 3-5-8 Saiwai Cho, Fuchu, Tokyo 1838509, Japan
[2] Benha Univ, Fac Vet Med, Dept Pharmacol, Toukh 13736, Elqaliobiya, Egypt
[3] Kitasato Univ, Sch Vet Med, Lab Vet Pharmacol, Towada, Aomori 0348628, Japan
来源：
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES | 2019年 / 20卷 / 09期
基金：
日本学术振兴会;
关键词：
c-Myc; cancer organoid; colorectal cancer; cancer stem cell; HUMAN HEPATOCELLULAR-CARCINOMA; COLON-CANCER; GENOMIC INSTABILITY; BURKITT-LYMPHOMA; CYCLE ARREST; INHIBITS PROLIFERATION; INDUCED APOPTOSIS; TUMOR-SUPPRESSOR; GENE-EXPRESSION; POOR-PROGNOSIS;
D O I：
10.3390/ijms20092340
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
Myc is a nuclear transcription factor that mainly regulates cell growth, cell cycle, metabolism, and survival. Myc family proteins contain c-Myc, n-Myc, and l-Myc. Among them, c-Myc can become a promising therapeutic target molecule in cancer. Cancer stem cells (CSCs) are known to be responsible for the therapeutic resistance. In the previous study, we demonstrated that c-Myc mediates drug resistance of colorectal CSCs using a patient-derived primary three-dimensional (3D) organoid culture. In this review, we mainly focus on the roles of c-Myc-related signaling in the regulation of CSCs, chemotherapy resistance, and colorectal cancer organoids. Finally, we introduce the various types of c-Myc inhibitors and propose the possibility of c-Myc as a therapeutic target against colorectal cancer.
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页数：16
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