Emerging Roles of C-Myc in Cancer Stem Cell-Related Signaling and Resistance to Cancer Chemotherapy: A Potential Therapeutic Target Against Colorectal Cancer

被引：182

作者：

Elbadawy, Mohamed ^{[1
,2
]}

Usui, Tatsuya ^{[1
]}

Yamawaki, Hideyuki ^{[3
]}

Sasaki, Kazuaki ^{[1
]}

机构：

[1] Tokyo Univ Agr & Technol, Fac Agr, Dept Vet Med, Lab Vet Pharmacol, 3-5-8 Saiwai Cho, Fuchu, Tokyo 1838509, Japan

[2] Benha Univ, Fac Vet Med, Dept Pharmacol, Toukh 13736, Elqaliobiya, Egypt

[3] Kitasato Univ, Sch Vet Med, Lab Vet Pharmacol, Towada, Aomori 0348628, Japan

来源：

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES | 2019年 / 20卷 / 09期

基金：

日本学术振兴会;

关键词：

c-Myc; cancer organoid; colorectal cancer; cancer stem cell; HUMAN HEPATOCELLULAR-CARCINOMA; COLON-CANCER; GENOMIC INSTABILITY; BURKITT-LYMPHOMA; CYCLE ARREST; INHIBITS PROLIFERATION; INDUCED APOPTOSIS; TUMOR-SUPPRESSOR; GENE-EXPRESSION; POOR-PROGNOSIS;

D O I：

10.3390/ijms20092340

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Myc is a nuclear transcription factor that mainly regulates cell growth, cell cycle, metabolism, and survival. Myc family proteins contain c-Myc, n-Myc, and l-Myc. Among them, c-Myc can become a promising therapeutic target molecule in cancer. Cancer stem cells (CSCs) are known to be responsible for the therapeutic resistance. In the previous study, we demonstrated that c-Myc mediates drug resistance of colorectal CSCs using a patient-derived primary three-dimensional (3D) organoid culture. In this review, we mainly focus on the roles of c-Myc-related signaling in the regulation of CSCs, chemotherapy resistance, and colorectal cancer organoids. Finally, we introduce the various types of c-Myc inhibitors and propose the possibility of c-Myc as a therapeutic target against colorectal cancer.

引用

页数：16

共 138 条

[1] THE C-MYC ONCOGENE DRIVEN BY IMMUNOGLOBULIN ENHANCERS INDUCES LYMPHOID MALIGNANCY IN TRANSGENIC MICE
ADAMS, JM
HARRIS, AW
PINKERT, CA
CORCORAN, LM
ALEXANDER, WS
CORY, S
PALMITER, RD
BRINSTER, RL
[J]. NATURE, 1985, 318 (6046) : 533 - 538
[2] Ovarian cancer: Strategies for overcoming resistance to chemotherapy
Agarwal, R
Kaye, SB
[J]. NATURE REVIEWS CANCER, 2003, 3 (07) : 502 - 516
[3] Genome instability:: a mechanistic view of its causes and consequences
Aguilera, Andres
Gomez-Gonzalez, Belen
[J]. NATURE REVIEWS GENETICS, 2008, 9 (03) : 204 - 217
[4] Gli1, downregulated in colorectal cancers, inhibits proliferation of colon cancer cells involving Wnt signalling activation
Akiyoshi, T.
Nakamura, M.
Koga, K.
Nakashima, H.
Yao, T.
Tsuneyoshi, M.
Tanaka, M.
Katano, M.
[J]. GUT, 2006, 55 (07) : 991 - 999
[5] MYC in Oncogenesis and as a Target for Cancer Therapies
Albihn, Ami
Johnsen, John Inge
Henriksson, Marie Arsenian
[J]. ADVANCES IN CANCER RESEARCH, VOL 107, 2010, 107 : 163 - 224
[6] Mastermind-like 1 is a specific coactivator of β-catenin transcription activation and is essential for colon carcinoma cell survival
Alves-Guerra, Marie-Clotilde
Ronchini, Chiara
Capobianco, Anthony J.
[J]. CANCER RESEARCH, 2007, 67 (18) : 8690 - 8698
[7] Amati Bruno, 1998, Frontiers in Bioscience, V3, pD250
[8] [Anonymous], CURR PROTOC TOXICOL
[9] Stem cell-derived organoids and their application for medical research and patient treatment
Bartfeld, Sina
Clevers, Hans
[J]. JOURNAL OF MOLECULAR MEDICINE-JMM, 2017, 95 (07): : 729 - 738
[10] Batsaikhan BE, 2014, ANTICANCER RES, V34, P6339

← 1 2 3 4 5 6 7 8 9 10 →