OCCURRENCE AND STRUCTURAL DIVERSITY OF FUNGAL METABOLITES WITH ANTIBIOTIC ACTIVITY

被引：12

作者：

Takahashi, Jacqueline Aparecida ^{[1
]}

Ferreira Lucas, Esther Maria ^{[1
]}

机构：

[1] Univ Fed Minas Gerais, Dept Quim, Inst Ciencias Exatas, BR-31270010 Belo Horizonte, MG, Brazil

来源：

QUIMICA NOVA | 2008年 / 31卷 / 07期

关键词：

fungal metabolites; antibiotics; fermentation;

D O I：

10.1590/S0100-40422008000700036

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

Several reasons motivated the development of new generations of antibiotics, such as their high ability to develop resistance to virtually all kinds of anti-infective agents and the crescent market demand for new drugs to treat special demanding patients. After penicillin discovery, several antibiotics were developed from fungal metabolites, since antibacterial secondary metabolites consists on a fungal endogenous protective mechanism against natural competitors. The aim of this review is to present the structural diversity of antibacterial and antifungal metabolites produced by fungi, mentioning sources of fungal isolates, cultivation process and details on the scope of their antibiotic activity.

引用

页码：1807 / 1813

页数：7

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