Concise Review: Two negative feedback loops place mesenchymal stem/stromal cells at the center of early regulators of inflammation

被引:175
作者
Prockop, Darwin J. [1 ]
机构
[1] Scott & White Mem Hosp & Clin, Texas A&M Hlth Sci Ctr, Coll Med, Inst Regenerat Med, Temple, TX 76502 USA
关键词
Anti-inflammatory; Prostaglandin E2; TNF alpha stimulated gene/protein 6; Immune regulation; ANTIINFLAMMATORY PROTEIN TSG-6; STEM-CELLS; STROMAL CELLS; STERILE INFLAMMATION; PROSTAGLANDIN E-2; INNATE IMMUNITY; BONE; MACROPHAGES; DAMAGE; CORNEA;
D O I
10.1002/stem.1400
中图分类号
Q813 [细胞工程];
学科分类号
摘要
Recent data demonstrated that MSCs can be activated by proinflammatory signals to introduce two negative feedback loops into the generic pathway of inflammation. In one loop, the activated MSCs secrete PGE2 that drives resident macrophages with an M1 proinflammatory phenotype toward an M2 anti-inflammatory phenotype. In the second loop, the activated MSCs secrete TSG-6 that interacts with CD44 on resident macrophages to decrease TLR2/NF kappa-B signaling and thereby decrease the secretion of proinflammatory mediators of inflammation. The PGE2 and TSG-6 negative feedback loops allow MSCs to serve as regulators of the very early phases of inflammation. These and many related observations suggest that the MSC-like cells found in most tissues may be part of the pantheon of cells that protect us from foreign invaders, tissue injury, and aging. STEM Cells 2013;31:2042-2046
引用
收藏
页码:2042 / 2046
页数:5
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