Orexin-A microinjection into the rostral ventromedial medulla causes antinociception on formalin test

被引：27
作者：
Azhdari-Zarmehri, Hassan [1 ,2 ]
Semnanian, Saeed [2 ]
Fathollahi, Yaghoub [2 ]
机构：
[1] Torbat Heydariyeh Univ Med Sci, Dept Basic Sci, Torbat Heydariyeh, Iran
[2] Tarbiat Modares Univ, Sch Med Sci, Dept Physiol, Tehran, Iran
来源：
PHARMACOLOGY BIOCHEMISTRY AND BEHAVIOR | 2014年 / 122卷
关键词：
Orexin-A; Rostral ventromedial medulla; Orexin receptor 1; Formalin test; LATERAL HYPOTHALAMUS; RAT-BRAIN; HOT PLATE; PAIN; RECEPTORS; MICE; HYPOCRETIN-1; STIMULATION; MODULATION; MORPHINE;
D O I：
10.1016/j.pbb.2014.03.017
中图分类号：
B84 [心理学]; C [社会科学总论]; Q98 [人类学];
学科分类号：
03 ; 0303 ; 030303 ; 04 ; 0402 ;
摘要：
Orexins are produced from neurons which are restricted to a few regions of the lateral hypothalamus (LH), where they are important in pain modulation. The orexin receptors and orexinergic projections are localized in regions previously shown to play a role in pain modulation such as rostral ventromedial medulla (RVM). The effect of orexin-A (ORXA) microinjection into the RVM on nociceptive behaviors was examined using the formalin test. Microinjection of ORXA into the RVM, but not adjacent reticularis gigantocellularis (Gi) nucleus, decreased formalin induced nociceptive behaviors. Pretreatment with a selective OX1R antagonist, SB-334867 inhibited the antinociception produced by ORXA, while the administration of SB-334867 alone had no effect. These data demonstrate that ORXA-induced antinociception in the formalin test is mediated in part through orexin1 receptors in the RVM. (C) 2014 Published by Elsevier Inc.
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收藏
页码：286 / 290
页数：5
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