Synthesis of α-haloenamides via zinc halide mediated direct addition of benzhydryl halides to ynamides

被引：10

作者：

Chen, Ling ^{[1
]}

Yu, Lian ^{[1
]}

Deng, Yuan ^{[1
]}

Cui, Yuming ^{[1
]}

Bian, Gaofeng ^{[1
]}

Cao, Jian ^{[1
]}

机构：

[1] Hangzhou Normal Univ, Key Lab Organosilicon Chem & Mat Technol, Minist Educ, Hangzhou, Zhejiang, Peoples R China

来源：

ORGANIC & BIOMOLECULAR CHEMISTRY | 2016年 / 14卷 / 02期

基金：

中国国家自然科学基金;

关键词：

STEREOSELECTIVE-SYNTHESIS; ENAMIDES; CYCLOISOMERIZATION; REGIO; MILD;

D O I：

10.1039/c5ob01950h

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

A regio- and stereoselective synthesis of highly substituted alpha-haloenamides was described via the zinc halide mediated direct addition of benzhydryl halides to ynamides under mild conditions. The products alpha-haloenamides were further transformed into multisubstituted enamides via Suzuki and Sonogashira cross-coupling reactions.

引用

页码：564 / 569

页数：6

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