Sex differences in nevirapine disposition in HIV-infected patients

被引：18

作者：

Regazzi, M ^{[1
]}

Villani, P

Seminari, E

Ravasi, G

Cusato, M

Marubbi, F

Meneghetti, G

Maserati, R

机构：

[1] Policlin San Matteo, IRCCS, Dept Pharmacol, I-27100 Pavia, Italy

[2] Policlin San Matteo, IRCCS, Dept Infect Dis, I-27100 Pavia, Italy

来源：

AIDS | 2003年 / 17卷 / 16期

关键词：

D O I：

10.1097/00002030-200311070-00018

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

To evaluate the role of sex in nevirapine pharmacokinetics, we analysed the pharmacokinetic profile of nevirapine in 11 male and 11 female HIV-positive patients chronically treated with nevirapine 400 mg once a day. Statistically significant inter-group differences in the plasma concentration and fluctuations between that and the concentration just before the next dose, at steady-state, were observed. Variations in lean body mass and composition affecting nevirapine distribution might account for inter-sex discrepancies in nevirapine plasma levels.

引用

页码：2399 / 2400

页数：2

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