Differential clinical characteristics of acute liver failure caused by hemophagocytic lymphohistiocytosis in children

被引：19

作者：

Ryu, Jeong-Min ^{[1
]}

Kim, Kyung Mo ^{[2
]}

Oh, Seak Hee ^{[2
]}

Koh, Kyung Nam ^{[2
]}

Im, Ho Joon ^{[2
]}

Park, Chan-Jeoung ^{[3
]}

Chi, Hyun-Sook ^{[3
]}

Seo, Jong Jin ^{[2
]}

机构：

[1] Univ Ulsan, Childrens Hosp, Asan Med Ctr, Dept Pediat Emergency Med,Coll Med, Seoul 138736, South Korea

[2] Univ Ulsan, Childrens Hosp, Asan Med Ctr, Dept Pediat,Coll Med, Seoul 138736, South Korea

[3] Univ Ulsan, Coll Med, Asan Med Ctr, Dept Lab Med, Seoul 138736, South Korea

来源：

PEDIATRICS INTERNATIONAL | 2013年 / 55卷 / 06期

关键词：

acute liver failure; child; hemophagocytic lymphohistiocytosis; liver transplantation; FULMINANT HEPATIC-FAILURE; EPSTEIN-BARR-VIRUS; TRANSPLANTATION; HISTIOCYTOSIS; INFANTS;

D O I：

10.1111/ped.12181

中图分类号：

R72 [儿科学];

学科分类号：

100202 ;

摘要：

BackgroundChildren with acute liver failure (ALF) caused by hemophagocytic lymphohistiocytosis (HLH) may be at risk of undergoing unnecessary liver transplantation (LT). The aim of this study was to compare the characteristics of ALF caused by HLH with those of ALF of unknown etiology in children. MethodsThe clinical features and laboratory findings for eight children with ALF caused by HLH (ALF-HLH group) and 27 children with ALF of unknown etiology (ALF-UK group) were retrospectively compared by reviewing medical records. ResultsThe ALF-HLH group had a higher incidence of pleural effusion, C-reactive protein elevation (especially >5mg/dL), thrombocytopenia, anemia, fever, splenomegaly, and hypoalbuminemia (<2.5mg/dL), and a higher in-hospital mortality rate. No significant differences were found in the white blood cell count, liver enzymes, coagulation profile, or incidence of hepatomegaly. ConclusionsLT should be performed only after it is proven that ALF is not caused by HLH, if a child with ALF shows the differential clinical features of ALF caused by HLH. Further research with larger sample sizes, however, is needed.

引用

页码：748 / 752

页数：5

共 30 条

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