Sarcoma response to targeted therapy dynamically polarizes tumor-associated macrophages

被引：5

作者：

Cavnar, Michael J. ^{[1
]}

DeMatteo, Ronald P. ^{[1
]}

机构：

[1] Mem Sloan Kettering Canc Ctr, New York, NY 10021 USA

来源：

ONCOIMMUNOLOGY | 2014年 / 3卷 / 04期

关键词：

tumor-associated macrophage; gastrointestinal stromal tumor; macrophage; CSF1R; C/EBP beta;

D O I：

10.4161/onci.28463

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

In gastrointestinal stromal tumor (GIST), the most common human sarcoma, tumor-associated macrophages (TAMs) have been found to be abundant and surprisingly M1-like, exhibiting antitumoral activities. However, TAMs switch to M2-like during the course of imatinib therapy, but upon drug resistance TAMs revert to M1-like. Therefore, the oncologic efficacy of TAM depletion may depend on tumor type and treatment status.

引用

页数：3

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