KNL1: bringing order to the kinetochore

被引：46

作者：

Caldas, Gina V. ^{[1
]}

DeLuca, Jennifer G. ^{[1
]}

机构：

[1] Colorado State Univ, Dept Biochem & Mol Biol, Ft Collins, CO 80523 USA

来源：

CHROMOSOMA | 2014年 / 123卷 / 03期

基金：

美国国家卫生研究院;

关键词：

KNL1; Kinetochore; Mitosis; SAC activation; SAC silencing; Chromosome congression; SPINDLE-ASSEMBLY CHECKPOINT; INTRINSICALLY DISORDERED PROTEINS; FAITHFUL CHROMOSOME SEGREGATION; CENP-E; MICROTUBULE ATTACHMENT; MITOTIC CHECKPOINT; OUTER KINETOCHORE; FISSION YEAST; AURORA-B; SACCHAROMYCES-CEREVISIAE;

D O I：

10.1007/s00412-013-0446-5

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

KNL1 is an evolutionarily conserved kinetochore-associated protein essential for accurate chromosome segregation in eukaryotic cells. This large scaffold protein, predicted to be almost entirely unstructured, is involved in diverse mitotic processes including kinetochore assembly, chromosome congression, and mitotic checkpoint signaling. How this kinetochore "hub" coordinates protein-protein interactions spatially and temporally during mitosis to orchestrate these processes is an area of active investigation. Here we summarize the current understanding of KNL1 and discuss possible mechanisms by which this protein actively contributes to multiple aspects of mitotic progression.

引用

页码：169 / 181

页数：13

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