Exploring conditional gene essentiality through systems genetics approaches in yeast

被引：10

作者：

Bosch-Guiteras, Nuria ^{[1
]}

van Leeuwen, Jolanda ^{[1
]}

机构：

[1] Univ Lausanne, Ctr Integrat Genom, Lausanne, Switzerland

来源：

CURRENT OPINION IN GENETICS & DEVELOPMENT | 2022年 / 76卷

基金：

瑞士国家科学基金会;

关键词：

GENOME; EXPLORATION;

D O I：

10.1016/j.gde.2022.101963

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

An essential gene encodes for a cellular function that is required for viability. Although viability is a straightforward phenotype to analyze in yeast, defining a gene as essential is not always trivial. Gene essentiality has generally been studied in specific laboratory strains and under standard growth conditions, however, essentiality can vary across species, strains, and environments. Recent systematic studies of gene essentiality revealed that two sets of essential genes exist: core essential genes that are always required for viability and conditional essential genes that vary in essentiality in different genetic and environmental contexts. Here, we review recent advances made in the systematic analysis of gene essentiality in yeast and discuss the properties that distinguish core from context-dependent essential genes.

引用

页数：7

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