Tumor-Targeted DNA Bipyramid for in Vivo Dual -Modality Imaging

被引：11
作者：
Song, Linlin [1 ]
Wang, Zhaoran [1 ]
Liu, Jianbing [1 ]
Wang, Ting [1 ]
Jiang, Qiao [1 ]
Ding, Baoquan [1 ,2 ,3 ]
机构：
[1] Natl Ctr NanoSci & Technol, Beijing, Peoples R China
[2] Univ Chinese Acad Sci, Beijing, Peoples R China
[3] Zhengzhou Univ, Zhengzhou, Peoples R China
来源：
ACS APPLIED BIO MATERIALS | 2020年 / 3卷 / 05期
基金：
中国国家自然科学基金;
关键词：
DNA bipyramid nanostructure; tumor-targeted; dual-modality imaging; magnetic resonance; imaging; near-infrared fluorescence imaging; DRUG-DELIVERY; NANOSTRUCTURES; NANOPROBES;
D O I：
10.1021/acsabm.9b01096
中图分类号：
TB3 [工程材料学];
学科分类号：
0805 ; 080502 ;
摘要：
A versatile DNA bipyramid nanostructure is assembled as a tumor-targeted, dual-modal nanoprobe for in vivo imaging. Magnetic resonance contrast agents (Gd-DOTA), fluorescence imaging molecules (Dylight800), and tumor-targeting moieties (anti-EGFR aptamers) were precisely organized on the DNA bipyramid platform. DNA bipyramids coated by polyethylene glycol-polylysine copolymer showed enhanced resistance against digestion in serum and prolonged circulation time in vivo. The multifunctional DNA bipyramid improved codelivery of magnetic resonance/fluorescence imaging (MR/FI) contrast agents to triple-negative breast tumors, realizing noninvasive tumor imaging without observable systemic toxicity. Our rationally designed DNA-based platform will prove powerful to develop customized molecular probes for cancer diagnosis.
引用
收藏
页码：2854 / 2860
页数：7
相关论文
共 29 条
  • [1] Block Copolymer Micellization as a Protection Strategy for DNA Origami
    Agarwal, Nayan P.
    Matthies, Michael
    Guer, Fatih N.
    Osada, Kensuke
    Schmidt, Thorsten L.
    [J]. ANGEWANDTE CHEMIE-INTERNATIONAL EDITION, 2017, 56 (20) : 5460 - 5464
  • [2] Gadolinium chelate coated gold nanoparticles as contrast agents for both X-ray computed tomography and magnetic resonance imaging
    Alric, Christophe
    Taleb, Jacqueline
    Le Duc, Geraldine
    Mandon, Celine
    Billotey, Claire
    Le Meur-Herland, Alice
    Brochard, Thierry
    Vocanson, Francis
    Janier, Marc
    Perriat, Pascal
    Roux, Stephane
    Tillement, Olivier
    [J]. JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, 2008, 130 (18) : 5908 - 5915
  • [3] The interplay of T1- and T2-relaxation on T1-weighted MRI of hMSCs induced by Gd-DOTA-peptides
    Cao, Limin
    Li, Binbin
    Yi, Peiwei
    Zhang, Hailu
    Dai, Jianwu
    Tan, Bo
    Deng, Zongwu
    [J]. BIOMATERIALS, 2014, 35 (13) : 4168 - 4174
  • [4] Recent advances in different modal imaging-guided photothermal therapy
    Chen, Qiwen
    Wen, Jia
    Li, Hongjuan
    Xu, Yongqian
    Liu, Fengyu
    Sun, Shiguo
    [J]. BIOMATERIALS, 2016, 106 : 144 - 166
  • [5] A self-assembled DNA bipyramid
    Erben, Christoph M.
    Goodman, Russell P.
    Turberfield, Andrew J.
    [J]. JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, 2007, 129 (22) : 6992 - +
  • [6] Quantizing single-molecule surface-enhanced Raman scattering with DNA origami metamolecules
    Fang, Weina
    Jia, Sisi
    Chao, Jie
    Wang, Liqian
    Duan, Xiaoyang
    Liu, Huajie
    Li, Qian
    Zuo, Xiaolei
    Wang, Lihua
    Wang, Lianhui
    Liu, Na
    Fan, Chunhai
    [J]. SCIENCE ADVANCES, 2019, 5 (09)
  • [7] Nanoprobes Visualizing Gliomas by Crossing the Blood Brain Tumor Barrier
    Gao, Xihui
    Li, Cong
    [J]. SMALL, 2014, 10 (03) : 426 - 440
  • [8] Tumor Microenvironment-Triggered Aggregation of Antiphagocytosis 99mTc-Labeled Fe3O4 Nanoprobes for Enhanced Tumor Imaging In Vivo
    Gao, Zhenyu
    Hou, Yi
    Zeng, Jianfeng
    Chen, Lei
    Liu, Chunyan
    Yang, Wensheng
    Gao, Mingyuan
    [J]. ADVANCED MATERIALS, 2017, 29 (24)
  • [9] DNA Nanotechnology-Enabled Drug Delivery Systems
    Hu, Qinqin
    Li, Hua
    Wang, Lihua
    Gu, Hongzhou
    Fan, Chunhai
    [J]. CHEMICAL REVIEWS, 2019, 119 (10) : 6459 - 6506
  • [10] Huang XL, 2018, CHEM SOC REV, V47, P2873, DOI [10.1039/c7cs00612h, 10.1039/C7CS00612H]
123