Synthetic and mechanistic studies of the cycloisomerization and cyclization/hydrosilylation of functionalized dienes catalyzed by cationic palladium(II) complexes

被引：143
作者：
Widenhoefer, RA [1 ]
机构：
[1] Duke Univ, PM Gross Chem Lab, Durham, NC 27708 USA
来源：
ACCOUNTS OF CHEMICAL RESEARCH | 2002年 / 35卷 / 10期
关键词：
D O I：
10.1021/ar010040n
中图分类号：
O6 [化学];
学科分类号：
0703 ;
摘要：
This Account describes the development and mechanistic study of the cycloisomerization and cyclization/hydrosilylation of functionalized dienes catalyzed by cationic palladium (II), complexes. These transformations are characterized by good functional group compatibility, high regio- and stereoselectivity, and low air- and moisture-sensitivity. Mechanistic studies of palladium phenanthroline-catalyzed diene cycloisomerization and cyclization/hydrosilylation established mechanisms involving C-C bond formation via intramolecular carbometalation of an alkyl olefin chelate complex, which was directly observed in the context of cyclization/hydrositylation.
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页码：905 / 913
页数：9
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