Transcriptional Activity of Chromosome Nucleolar Organizing Regions in Population of Kursk Region

被引：25

作者：

Amelina, I. V. ^{[1
]}

Medvedev, I. N. ^{[1
]}

机构：

[1] Branch Russian State Social Univ, Kursk Inst Social Educ, Moscow, Russia

来源：

BULLETIN OF EXPERIMENTAL BIOLOGY AND MEDICINE | 2009年 / 147卷 / 06期

关键词：

nucleolar organizing regions; Ag-method; Ag-polymorphism; erythrocyte membrane proteins;

D O I：

10.1007/s10517-009-0592-1

中图分类号：

R-3 [医学研究方法]; R3 [基础医学];

学科分类号：

1001 ;

摘要：

We studied population polymorphism of active nucleolar organizing regions in residents of the Kursk region and the association of activity of chromosomal nucleolar organizing regions with intensity of the synthesis of erythrocyte membrane protein. We revealed a tendency towards increasing of the amount of the major erythrocyte membrane proteins (primarily, spectrins and band 5 protein) with increasing total transcriptional activity of nucleolar organizing regions of chromosomes. The intensity of protein synthesis affects cell proliferation, determines the rate of tissue growth and its function, which determines its participation in the development of various diseases.

引用

页码：730 / 732

页数：3