A DNA-binding Gd chelate for the detection of cell death by MRI

被引：29

作者：

Garanger, Elisabeth ^{[1
]}

Hilderbrand, Scott A. ^{[1
]}

Blois, Joseph T. ^{[1
]}

Sosnovik, David E. ^{[1
,2
]}

Weissleder, Ralph ^{[1
,3
,4
]}

Josephson, Lee ^{[1
]}

机构：

[1] Harvard Univ, Massachusetts Gen Hosp, Sch Med, Ctr Mol Imaging Res, Boston, MA 02115 USA

[2] Harvard Univ, Massachusetts Gen Hosp, Sch Med, Div Cardiol, Boston, MA USA

[3] Harvard Univ, Massachusetts Gen Hosp, Sch Med, Ctr Syst Biol, Boston, MA USA

[4] Harvard Univ, Sch Med, Dept Syst Biol, Boston, MA USA

来源：

CHEMICAL COMMUNICATIONS | 2009年 / 29期

关键词：

THIAZOLE ORANGE; ANNEXIN-V; IN-VIVO; APOPTOSIS; DYE;

D O I：

10.1039/b907375b

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

GadoTO, a MR contrast agent for the detection of cell death, consists of a nucleic acid-binding fluorophore attached to a gadolinium chelate.

引用

页码：4444 / 4446

页数：3

共 14 条

[1] Quantitative analysis of apoptotic cell death using proton nuclear magnetic resonance spectroscopy [J].

Blankenberg, FG ;

Katsikis, PD ;

Storrs, RW ;

Beaulieu, C ;

Spielman, D ;

Chen, JY ;

Naumovski, L ;

Tait, JF .

BLOOD, 1997, 89 (10) :3778-3786

[2] In vivo imaging of apoptosis [J].

Blankenberg, Francis G. .

CANCER BIOLOGY & THERAPY, 2008, 7 (10) :1525-1532

[3] Sequence-specific fluorescence detection of DNA by polyamide-thiazole orange conjugates [J].

Fechter, EJ ;

Olenyuk, B ;

Dervan, PB .

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, 2005, 127 (47) :16685-16691

[4] Noninvasive imaging of apoptosis in cardiovascular disease [J].

Korngold, Ethan Chauncey ;

Jaffer, Farouc Amin ;

Weissleder, Ralph ;

Sosnovik, David Edwin .

HEART FAILURE REVIEWS, 2008, 13 (02) :163-173

[5]

LAUFFER R B, 1990, Magnetic Resonance Quarterly, V6, P65

[6] THIAZOLE ORANGE - A NEW DYE FOR RETICULOCYTE ANALYSIS [J].

LEE, LG ;

CHEN, CH ;

CHIU, LA .

CYTOMETRY, 1986, 7 (06) :508-517

[7]

MAJNO G, 1995, AM J PATHOL, V146, P3

[8] Annexin-V imaging for noninvasive detection of cardiac allograft rejection [J].

Narula, J ;

Acio, ER ;

Narula, N ;

Samuels, LE ;

Fyfe, B ;

Wood, D ;

Fitzpatrick, JM ;

Raghunath, PN ;

Tomaszewski, JE ;

Kelly, C ;

Steinmetz, N ;

Green, A ;

Tait, JF ;

Leppo, J ;

Blankenberg, FG ;

Jain, D ;

Strauss, HW .

NATURE MEDICINE, 2001, 7 (12) :1347-1352

[9]

Poot M, 1997, CYTOMETRY, V27, P358, DOI 10.1002/(SICI)1097-0320(19970401)27:4<358::AID-CYTO7>3.0.CO

[10]

2-8

← 1 2 →