Controlled release of hydrogen sulfide significantly reduces ROS stress and increases dopamine levels in transgenic C. elegans

被引：15

作者：

Ali, Rafat ^{[1
,2
]}

Pal, Hilal Ahmad ^{[1
,2
]}

Hameed, Rohil ^{[3
]}

Nazir, Aamir ^{[3
]}

Verma, Sandeep ^{[1
,2
]}

机构：

[1] Indian Inst Technol Kanpur, Dept Chem, Kanpur 208016, UP, India

[2] Indian Inst Technol Kanpur, Ctr Nanosci, Kanpur 208016, UP, India

[3] CSIR, Cent Drug Res Inst, Div Neurosci & Ageing Biol, BS-10-1,Sect 10,Sitapur Rd, Lucknow 226031, Uttar Pradesh, India

来源：

CHEMICAL COMMUNICATIONS | 2019年 / 55卷 / 68期

关键词：

CAENORHABDITIS-ELEGANS; OXIDATIVE STRESS; H2S; INFLAMMATION; MECHANISM; MOLECULE; INSIGHTS; GYY4137; DESIGN; MODEL;

D O I：

10.1039/c9cc05153h

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

Hydrogen sulfide, an endogenous signalling molecule, is central to several pathophysiological processes in mammalian systems. It scavenges reactive oxygen species and is known to ameliorate dopaminergic neuronal degeneration in neurotoxin-induced Parkinson's disease models. The rapid volatilization of H2S from spontaneously releasing sulfide salts being a challenge, we describe peptide conjugates which exhibit tris(2-carboxyethyl)phosphine mediated "slow and sustained" H2S release. These conjugates reduced hydrogen peroxide-induced oxidative stress and significantly increased dopamine levels in transgenic C. elegans.

引用

页码：10142 / 10145

页数：4

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