Asymmetric organic catalysis with modified cinchona alkaloids

被引：571

作者：

Tian, SK ^{[1
]}

Chen, YG ^{[1
]}

Hang, JF ^{[1
]}

Tang, L ^{[1
]}

McDaid, P ^{[1
]}

Deng, L ^{[1
]}

机构：

[1] Brandeis Univ, Dept Chem, Waltham, MA 02454 USA

来源：

ACCOUNTS OF CHEMICAL RESEARCH | 2004年 / 37卷 / 08期

关键词：

D O I：

10.1021/ar030048s

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

Insights into the role played by modified cinchona alkaloids in the Sharpless asymmetric dihydroxylation inspired studies of modified cinchona alkaloids as chiral organic catalysts that lead to the development of highly enantio selective alcoholyses for the desymmetrization, kinetic resolution, and dynamic kinetic resolution of cyclic anhydrides, cyanation of ketones, and 1,4-addition of thiols to cylic enones. These studies demonstrate the potential of modified cinchona alkaloids as broadly useful chiral organic catalysts for asymmetric synthesis.

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页码：621 / 631

页数：11

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