Involvement of CD8+ T Cells in Multiple Sclerosis

被引：96

作者：

Salou, Marion ^{[1
,2
]}

Nicol, Bryan ^{[1
,2
]}

Garcia, Alexandra ^{[1
,3
]}

Laplaud, David-Axel ^{[1
,4
,5
]}

机构：

[1] INSERM, UMR 1064, Nantes, France

[2] Univ Nantes, Dept Med, Nantes, France

[3] Nantes Hosp, ITUN, Nantes, France

[4] Nantes Hosp, Dept Neurol, Nantes, France

[5] INSERM 004, Ctr Invest Clin, Nantes, France

来源：

FRONTIERS IN IMMUNOLOGY | 2015年 / 6卷

关键词：

multiple sclerosis; autoimmunity; CD8(+) T cells; CENTRAL-NERVOUS-SYSTEM; CLASS-I MOLECULES; CEREBROSPINAL-FLUID; MAIT CELLS; CLONAL EXPANSIONS; PERIPHERAL-BLOOD; ANTIGEN; RESPONSES; LESIONS; LYMPHOCYTES;

D O I：

10.3389/fimmu.2015.00604

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Multiple sclerosis (MS) is a chronic autoimmune disease of the central nervous system characterized by focal demyelination patches associated with inflammatory infiltrates containing T lymphocytes. For decades, CD4(+) T cells have been recognized as playing a major role in the disease, especially in animal models, which has led to the development of several therapies. However, interest has recently developed in the involvement of CD8(+) T cells in MS following the analysis of infiltrating T cells in human brain lesions. A broad range of evidence now suggests that the pathological role of this T cell subset in MS may have been underestimated. In this review, we summarize the literature implicating CID8(+) T cells in the pathophysiology of MS. We present data from studies in the fields of genetics, anatomopathology and immunology, mainly in humans but also in animal models of MS. Altogether, this strongly suggests that CD8(+) T cells may be major effectors in the disease process, and that the development of treatments specifically targeting this subset would be germane.

引用

页数：9

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