Sorbs1 and-2 Interact with CrkL and Are Required for Acetylcholine Receptor Cluster Formation

被引：28

作者：

Hallock, Peter T. ^{[1
]}

Chin, Sherry ^{[1
]}

Blais, Steven ^{[2
]}

Neubert, Thomas A. ^{[2
]}

Glass, David J. ^{[1
]}

机构：

[1] Novartis Inst Biomed Res, Cambridge, MA 02139 USA

[2] NYU, Sch Med, Skirball Inst Biomol Med, New York, NY USA

来源：

MOLECULAR AND CELLULAR BIOLOGY | 2016年 / 36卷 / 02期

关键词：

TYROSINE KINASE MUSK; NEUROMUSCULAR-JUNCTION; POSTSYNAPTIC APPARATUS; C-ABL; DOK-7; PROTEIN; MATURATION; MUTATIONS; MUSCLE; GENE;

D O I：

10.1128/MCB.00775-15

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Crk and CrkL are noncatalytic adaptor proteins necessary for the formation of neuromuscular synapses which function downstream of muscle-specific kinase (MuSK), a receptor tyrosine kinase expressed in skeletal muscle, and the MuSK binding protein Dok-7. How Crk/CrkL regulate neuromuscular endplate formation is not known. To better understand the roles of Crk/CrkL, we identified CrkL binding proteins using mass spectrometry and have identified Sorbs1 and Sorbs2 as two functionally redundant proteins that associate with the initiating MuSK/Dok-7/Crk/CrkL complex, regulate acetylcholine receptor (AChR) clustering in vitro, and are localized at synapses in vivo.

引用

页码：262 / 270

页数：9

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