Orthogonally Engineering Matrix Topography and Rigidity to Regulate Multicellular Morphology

被引：46

作者：

Hu, Benhui ^{[1
]}

Shi, Wenxiong ^{[1
]}

Wu, Yun-Long ^{[1
]}

Leow, Wan Ru ^{[1
]}

Cai, Pingqiang ^{[1
]}

Li, Shuzhou ^{[1
]}

Chen, Xiaodong ^{[1
]}

机构：

[1] Nanyang Technol Univ, Sch Mat Sci & Engn, Singapore 639798, Singapore

来源：

ADVANCED MATERIALS | 2014年 / 26卷 / 33期

基金：

新加坡国家研究基金会;

关键词：

topography; rigidity; polymer matrix; cell-matrix anchorage; multicellular behavior; COLLECTIVE CELL-MIGRATION; MOLECULAR-DYNAMICS; CANCER-CELLS; TRACTION FORCE; ADHESION; STIFFNESS; RELEASE; SUBSTRATE; BEHAVIOR; CAPTURE;

D O I：

10.1002/adma.201402489

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

Programmable polymer substrates, which mimic the variable extracellular matrices in living systems, are used to regulate multicellular morphology, via orthogonally modulating the matrix topography and elasticity. The multicellular morphology is dependent on the competition between cell-matrix adhesion and cell-cell adhesion. Decreasing the cell-matrix adhesion provokes cytoskeleton reorganization, inhibits lamellipodial crawling, and thus enhances the leakiness of multicellular morphology. © 2014 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.

引用

页码：5786 / 5793

页数：8

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