Research on antioxidant effects and estrogenic effect of formononetin from Trifolium pratense (red clover)

被引：129

作者：

Mu, H. ^{[1
]}

Bai, Y. -H. ^{[1
]}

Wang, S. -T. ^{[1
]}

Zhu, Z. -M. ^{[1
]}

Zhang, Y. -W. ^{[1
]}

机构：

[1] Xi An Jiao Tong Univ, Dept Chem, Sch Sci, Xian 710049, Peoples R China

来源：

PHYTOMEDICINE | 2009年 / 16卷 / 04期

关键词：

Formononetin; Isoflavone; Estrogenic effect; Antioxidant effect; Trifolium pratense (red clover); IN-VITRO; ISOFLAVONES; INHIBITION; METABOLISM;

D O I：

10.1016/j.phymed.2008.07.005

中图分类号：

Q94 [植物学];

学科分类号：

071001 ;

摘要：

Antioxidant and estrogenic effects of formononetin on ovariectomized mice have been investigated in the present study. The adult female Kunming mice were divided into 5 groups: sham-operated group, ovariectomized group, stilbestrol replacement therapy group (0.20 mg/kg day), low-dose formononetin group (0.05 g/kg day) and high-dose formononetin group (0.5 g/kg day). The mice in the latter 4 groups were ovariectomized. The drug was given by oral administration for 6 months. Estrogenic effect was determined by the change of uterine weight, and oxidant effects were determined by the content of SOD, GSH-Px, CAT and MDA. The intake of formononetin increased the uterine weight of the mice significantly as well as the content of SOD, GSH-Px, CAT, and reduced MDA in body. Formononetin had obvious antioxidant effects and estrogenic effect, and the estrogenic effect was not dosage-related. (C) 2008 Elsevier GmbH. All rights reserved.

引用

页码：314 / 319

页数：6

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