Enzymatic degradation of neuropeptide FF and SQA-neuropeptide FF in the mouse brain

被引：11
|
作者：
Sol, JC [1 ]
Roussin, A [1 ]
Proto, S [1 ]
Mazarguil, H [1 ]
Zajac, JM [1 ]
机构：
[1] CNRS, Inst Pharmacol & Biol Struct, F-31077 Toulouse, France
来源：
PEPTIDES | 1999年 / 20卷 / 10期
关键词：
neuropeptide FF; SQA-neuropeptide FF; degradation; peptidases; brain slices; mouse; capillary electrophoresis;
D O I：
10.1016/S0196-9781(99)00126-6
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
Degradation of neuropeptide FF (NPFF) and SQA-neuropeptide FF (SQA-NPFF) by mouse brain sections was investigated by using capillary electrophoresis with UV detection for the separation and the identification of the degradation products. The half disappearance time of SQA-NPFF was 2-fold greater than that of NPFF. NPFF was cleaved preferentially into an inactive metabolite, Gln-Arg-Phe-NH,, in the cerebrum slices. SQA-NPFF was hydrolyzed by an unidentified degrading activity to generate NPFF, and NPFF accounted for a larger part of SQA-NPFF degradation in the hindbrain and cervical spinal cord than in the cerebrum slices. These findings suggest that, depending on the brain regions, NPFF produced from SQA-NPFF could prolong the biologic effects of SQA-NPFF. (C) 1999 Elsevier Science Inc. All rights reserved.
引用
收藏
页码：1219 / 1227
页数：9
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