Long non-coding RNA FEZF1-AS1 promotes cell growth in multiple myeloma via miR-610/Akt3 axis

被引：39
作者：
Li, Qian-yu [1 ]
Chen, Li [1 ]
Hu, Ning [1 ]
Zhao, Hongmian [1 ]
机构：
[1] Henan Univ, Huaihe Hosp, Dept Hematol, Kaifeng 475000, Henan, Peoples R China
来源：
BIOMEDICINE & PHARMACOTHERAPY | 2018年 / 103卷
关键词：
FEZF1-AS1; miR-610; Akt3; Multiple myeloma; GASTRIC-CANCER; PROLIFERATION; EXPRESSION; PROGRESSION; MICRORNAS; INVASION;
D O I：
10.1016/j.biopha.2018.04.094
中图分类号：
R-3 [医学研究方法]; R3 [基础医学];
学科分类号：
1001 ;
摘要：
Increasing evidence showed that long non-coding RNAs (lncRNAs) play critical roles in tumor progression. FEZF1-AS1 is a cancer-associated lncRNA which upregulated and associated with poor prognosis in patients with cancer. However, the roles of FEZF1-AS1 in multiple myeloma (MM) remains unclear. In the present study, our data revealed that FEZF1-AS1 expression was increased both in MM samples and cell lines. Loss of functional assays indicated that FEZF1-AS1 suppression inhibited MM cells proliferation, arrested cell cycle in G0/G1 phase and induced cell apoptosis in vitro. Furthermore, our data indicated that FEZF1-AS1 functioned as a competing endogenous RNA in MM cells that regulated miR-610 expression, which suppressed Akt3. Those data showed that FEZF1-AS1 promoted MM cells proliferation through regulating miR-610/Akt3 axis, suggesting FEZF1-AS1 could be served as a potential target for cancer therapeutics in MM.
引用
收藏
页码：1727 / 1732
页数：6
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