Heterogeneous Copper-Catalyzed Cascade Three-Component Reaction of Amines, Carbon Disulfide and 2-Iodoanilines Leading to 2-Aminobenzothiazoles

被引：67

作者：

Zhao, Hong ^{[1
,2
,3
]}

He, Wen ^{[1
,2
]}

Yao, Ruiya ^{[1
,2
]}

Cai, Mingzhong ^{[1
,2
]}

机构：

[1] Jiangxi Normal Univ, Key Lab Funct Small Organ Mol, Minist Educ, Nanchang 330022, Peoples R China

[2] Jiangxi Normal Univ, Coll Chem & Chem Engn, Nanchang 330022, Peoples R China

[3] Guangdong Pharmaceut Univ, Sch Chem & Chem Engn, Guangzhou 510006, Guangdong, Peoples R China

来源：

ADVANCED SYNTHESIS & CATALYSIS | 2014年 / 356卷 / 14-15期

基金：

中国国家自然科学基金;

关键词：

2-aminobenzothiazoles; cascade reactions; functionalized MCM-41; heterogeneous catalysis; immobilized copper catalyst; MESOPOROUS MOLECULAR-SIEVES; S BOND FORMATION; N-ARYLATION; C-H; INTRAMOLECULAR CYCLIZATION; PARALLEL SYNTHESIS; COUPLING REACTIONS; DIRECT AMINATION; EFFICIENT; BENZOTHIAZOLES;

D O I：

10.1002/adsc.201400381

中图分类号：

O69 [应用化学];

学科分类号：

081704 ;

摘要：

The heterogeneous cascade three-component reaction of amines, carbon disulfide (CS2) and 2-iodoanilines was achieved in dimethylformamide (DMF) at 110 degrees C in the presence of 10 mol% of 3-(2-aminoethylamino) propyl-functionalized MCM-41-immobilized copper complex [MCM-41-2N-CuCl] using potassium carbonate (K2CO3) as base, yielding a variety of 2-aminobenzothiazoles in good to excellent yields. This heterogeneous copper catalyst influences the selectivity of the reaction and can be recovered and recycled by a simple filtration of the reaction solution and used for at least 10 consecutive trials without any decreases in activity.

引用

页码：3092 / 3098

页数：7

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