Erythrophagocytosis Enhances Heme-Dependent Cytotoxicity of Antimalarial Drugs in Canine Histiocytic Sarcoma Cell Line DH82

被引：2

作者：

Chikazawa, Seishiro ^{[1
]}

Kitahara, Yasunori ^{[1
]}

Ando, Erika ^{[1
]}

Hori, Yasutomo ^{[1
]}

Hoshi, Fumio ^{[1
]}

Kanai, Kazutaka ^{[1
]}

Ito, Naoyuki ^{[1
]}

Higuchi, Seiichi ^{[1
]}

机构：

[1] Kitasato Univ, Sch Vet Med, Dept Small Anim Internal Med, Towada, Aomori 0348628, Japan

来源：

JOURNAL OF VETERINARY MEDICAL SCIENCE | 2014年 / 76卷 / 02期

关键词：

artesunate; DH82; dihydroartemisinin; erythrophagocytosis; MALIGNANT HISTIOCYTOSIS; PHOTODYNAMIC THERAPY; IRON; DIHYDROARTEMISININ; ARTEMISININ; DOG; ACID;

D O I：

10.1292/jvms.13-0319

中图分类号：

S85 [动物医学（兽医学）];

学科分类号：

0906 ;

摘要：

Antimalarial drugs, dihydroartemisinin (DHA) and artesunate (ATS), exhibit iron-dependent cytotoxicity in tumor cells. We hypothesized that erythrophagocytic uptake of heme-iron enhances the cytotoxicity of DHA and ATS. Erythrophagocytic (EP) treatment of the canine histiocytic sarcoma cell line DH82 markedly increased the cytotoxicity of DHA and ATS compared to controls. Succinyl acetone, an inhibitor of intracellular heme synthesis, decreased the cytotoxicity of DHA and ATS in normal cells, but this change was not observed in EP cells. These results suggest that exogenous heme derived from erythrocytes can enhance the cytotoxicity of DHA and ATS. Furthermore, our study suggests that heme could be a novel component of tumor treatment in veterinary medicine.

引用

页码：249 / 253

页数：5

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