Drug-induced home cage conspecifics' behavior can potentiate behavioral sensitization in mice

被引:19
作者
Araujo, N. P.
Fukushiro, D. F.
Cunha, J. L. S.
Levin, R.
Chinen, C. C.
Carvalho, R. C.
Ribeiro, I. C. P.
Gomes, D. C.
Abilio, V. C.
Silva, R. H.
Ribeiro, R. de A.
Frussa-Filho, R.
机构
[1] Univ Fed Sao Paulo, UNIFESP, Dept Farmacol, BR-04023062 Sao Paulo, Brazil
[2] Univ Fed Sao Paulo, Dept Psicobiol, BR-04023062 Sao Paulo, Brazil
基金
巴西圣保罗研究基金会;
关键词
addiction; amphetamine; ethanol; open-field behavior; social learning;
D O I
10.1016/j.pbb.2006.04.019
中图分类号
B84 [心理学]; C [社会科学总论]; Q98 [人类学];
学科分类号
03 ; 0303 ; 030303 ; 04 ; 0402 ;
摘要
The effect of home cage conspecifics' behavior on locomotor sensitization to amphetamine (AMP) or ethanol (ETOH) were investigated. Female mice were repeatedly treated with saline or AMP (2.0 mg/kg for 13 days - Experiment 1) or saline or ETOH (1.8 g/kg for 21 days - Experiment 2) in home cages where all the animals had the same treatment (homogeneous home cages - HOM-HC) or in home cages where half of the animals were drug-treated and half of them were saline-treated (heterogeneous home cages - HET-HQ. Behavioral sensitization was evaluated by the quantification of open-field locomotor activity after AMP or ETOH challenge injection, respectively. In both experiments, behavioral sensitization was potentiated in HOM-HC maintained animals. These results suggest that the behavioral sensitization phenomenon can be modified by home cage conspecifics' behavior. (c) 2006 Elsevier Inc. All rights reserved.
引用
收藏
页码:142 / 147
页数:6
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