Amphotericin B dimers with bisamide linkage bearing powerful membrane-permeabilizing activity

被引：33

作者：

Yamaji, N ^{[1
]}

Matsumori, N ^{[1
]}

Matsuoka, S ^{[1
]}

Oishi, T ^{[1
]}

Murata, M ^{[1
]}

机构：

[1] Osaka Univ, Grad Sch Sci, Dept Chem, Toyonaka, Osaka 5600043, Japan

来源：

ORGANIC LETTERS | 2002年 / 4卷 / 12期

关键词：

D O I：

10.1021/ol025982m

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

[GRAPHIC] Covalently linked dimers of amphotericin B were prepared by cross-linking its carboxylic acid, Among these, a dimer with a linkage of 1,6-hexanediamine revealed potent hemolytic activity (EC50, 0.25 muM) while its N-acetyl derivative gave rise to large K+ ion flux in phosphatidylcholine liposomes, regardless of the presence or absence of sterols, suggesting that the dimers may serve as a tool for elucidating the structure of the ion channel assemblage formed by amphotericin B.

引用

页码：2087 / 2089

页数：3

共 37 条

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