The effects of baicalein and baicalin on mitochondrial function and dynamics: A review

被引：150

作者：

de Oliveira, Marcos Roberto ^{[1
]}

Nabavi, Seyed Fazel ^{[2
]}

Habtemariam, Solomon ^{[3
]}

Orhan, Ilkay Erdogan ^{[4
]}

Daglia, Maria ^{[5
]}

Nabavi, Seyed Mohammad ^{[2
]}

机构：

[1] Fed Univ Mato Grosso UFMT, ICET, Dept Chem, BR-78060900 Cuiaba, MT, Brazil

[2] Baqiyatallah Univ Med Sci, Appl Biotechnol Res Ctr, Tehran, Iran

[3] Univ Greenwich, Medway Sch Sci, Pharmacognosy Res Labs, Chatham ME4 4TB, Kent, England

[4] Gazi Univ, Fac Pharm, Dept Pharmacognosy, TR-06330 Ankara, Turkey

[5] Univ Pavia, Dept Drug Sci, Med Chem & Pharmaceut Technol Sect, I-27100 Pavia, Italy

来源：

PHARMACOLOGICAL RESEARCH | 2015年 / 100卷

关键词：

Antioxidant; Baicalin; Baicalein; Flavonoid; Mitochondria; MANGANESE SUPEROXIDE-DISMUTASE; APOPTOSIS-INDUCING FACTOR; PERFORMANCE LIQUID-CHROMATOGRAPHY; NECROSIS-FACTOR-ALPHA; NF-KAPPA-B; INTESTINAL 1ST-PASS METABOLISM; NANOSTRUCTURED LIPID CARRIERS; ACTIVITY-GUIDED ISOLATION; INDUCED OXIDATIVE STRESS; RAT-BRAIN MITOCHONDRIA;

D O I：

10.1016/j.phrs.2015.08.021

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

Mitochondria play an essential role in cell survival by providing energy, calcium buffering, and regulating apoptosis. A growing body of evidence shows that mitochondrial dysfunction and its consequences, including impairment of the mitochondrial respiratory chain, excessive generation of reactive oxygen species, and excitotoxicity, play a pivotal role in the pathogenesis of different diseases such as neurodegenerative diseases, neuropsychiatric disorders, and cancer. The therapeutical role of flavonoids on these diseases is gaining increasing acceptance. Numerous studies on experimental models have revealed the favorable role of flavonoids on mitochondrial function and structure. This review highlights the promising role of baicalin and its aglycone form, baicalein, on mitochondrial function and structure with a focus on its therapeutic effects. We also discuss their chemistry, sources and bioavailability. (C) 2015 Elsevier Ltd. All rights reserved.

引用

页码：296 / 308

页数：13

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