Impact evaluation of the routine hepatitis B vaccination program of infants in China

被引:8
作者
Sun, Mei [1 ,2 ]
Li, Chengyue [1 ,2 ]
Wu, Dan [1 ,2 ,3 ]
Li, Pingping [1 ,2 ,4 ]
Lu, Jun [1 ,2 ]
Wang, Ying [1 ,2 ]
Chang, Fengshui [1 ,2 ]
Li, Xiaohong [1 ,2 ]
Hao, Mo [1 ,2 ]
机构
[1] Fudan Univ, Res Inst Hlth Dev Strategies, 177 Box,130 Dongan Rd, Shanghai 200032, Peoples R China
[2] Fudan Univ, Collaborat Innovat Ctr Social Risks Governance Hl, Shanghai 200032, Peoples R China
[3] Shanghai Hlth Educ Inst, Shanghai 200000, Peoples R China
[4] Shanghai Childrens Med Ctr, Shanghai 200127, Peoples R China
基金
中国国家自然科学基金;
关键词
coverage with three doses of the vaccine; hepatitis B vaccination program of infants; impact evaluation; incidence of new hepatitis B infection; public policy; VIRUS INFECTION; TAIWAN; IMMUNIZATION; CHILDREN;
D O I
10.1093/pubmed/fdy015
中图分类号
R1 [预防医学、卫生学];
学科分类号
1004 ; 120402 ;
摘要
Background To evaluate the impact of the routine hepatitis B vaccination program of infants in China. Methods The incidence of new hepatitis B infection and coverage with three doses of the vaccines by age groups and provinces were derived from the National Network Direct Report System of Infectious Disease during 2004-10. Chi square test and Pearson correlation analysis were used to analyze differences in incidence according to vaccination coverage and the relationship between the coverage with three doses and the incidence in different provinces. Results The incidence of new infection was 8.96/100 000 among children with complete coverage (0-15 years old), which was significantly lower than that with partial or no coverage. Among 0-9-year-old children in 2010, the incidence of new infection was 6.36/100 000, which was significantly lower than 2004. Considering the impact of vaccination on cumulative incidence among 0-5-year-old children, a 2.2-fold greater incidence of new infection was observed in provinces with the lowest to the highest vaccination rate. Conclusion The impact of the routine hepatitis B vaccination program of infants in China has become more apparent over time. Program implementation and regional disequilibrium should be payed attention to as well as the expanded program.
引用
收藏
页码:158 / 163
页数:6
相关论文
共 32 条
[1]  
Akbar S. M. F., 2006, Current Topics in Virology. Volume 5, P31
[2]  
Anonymous, 2007, Morbidity and Mortality Weekly Report, V56, P441
[3]  
[Anonymous], 2016, HEP B
[4]  
[Anonymous], 2017, EX SUMM GLOB HEP REP
[5]   Legend of hepatitis B vaccination: The Taiwan experience [J].
Chan, CY ;
Lee, SD ;
Lo, KJ .
JOURNAL OF GASTROENTEROLOGY AND HEPATOLOGY, 2004, 19 (02) :121-126
[6]   Universal hepatitis B vaccination in Taiwan and the incidence of hepatocellular carcinoma in children [J].
Chang, MH ;
Chen, CJ ;
Lai, MS ;
Hsu, HM ;
Wu, TC ;
Kong, MS ;
Liang, DC ;
Shau, WY ;
Chen, DS .
NEW ENGLAND JOURNAL OF MEDICINE, 1997, 336 (26) :1855-1859
[7]   Progress in the control of hepatitis B infection in the Western Pacific Region [J].
Clements, CJ ;
Yang, BP ;
Crouch, A ;
Hipgrave, D ;
Mansoor, O ;
Nelson, CB ;
Treleaven, S ;
van Konkelenberg, R ;
Wiersma, S .
VACCINE, 2006, 24 (12) :1975-1982
[8]  
Cui F, 2008, CHINESE J VACCINES I, P413
[9]  
Damme PV, 1997, BMJ-BRIT MED J, V314, P1033
[10]  
Expanded programme on immunization, 1992, WKLY EPIDEMIOL REC, V67, P11