Encapsulation of rutin and naringenin in multilamellar vesicles for optimum antioxidant activity

被引：58

作者：

Kerdudo, Audrey ^{[1
,2
]}

Dingas, Alexandre ^{[1
]}

Fernandez, Xavier ^{[2
]}

Faure, Chrystel ^{[3
]}

机构：

[1] SOFIA Cosmet, F-06514 Carros, France

[2] Univ Nice Sophia Antipolis, ICN, UMR 7272, F-06108 Nice, France

[3] Univ Bordeaux, Lab Chim & Biol Membranes & Nanoobjets, CBMN, UMR 5248, F-33600 Pessac, France

来源：

FOOD CHEMISTRY | 2014年 / 159卷

关键词：

Encapsulation; Antioxidant activity; Flavonoids; Multilamellar vesicles; GASTRO-RESISTANT MICROPARTICLES; IN-VITRO; OXIDATIVE STRESS; LIPOSOMES; FLAVONOIDS; QUERCETIN; RELEASE; STABILITY; EXTRACT; CARRIER;

D O I：

10.1016/j.foodchem.2014.03.005

中图分类号：

O69 [应用化学];

学科分类号：

081704 ;

摘要：

Rutin and naringenin, two phenolic compounds with antioxidant properties were encapsulated in lipid-based onion-type multilamellar vesicles (MLVs). After vesicles formation, the free, adsorbed/encapsulated analytes were well separated with size exclusion chromatography (SEC), and rutin and naringenin were quantified with UV-HPLC at 258 nm and 290 nm. A mathematical model was developed to separately calculate the encapsulation and the adsorption yields of both phenols. Naringenin was shown to be poorly encapsulated (<10%) but highly adsorbed on MLVs surface (>60%) whatever MLVs composition. Conversely, rutin showed high encapsulation efficiency (>60%). Entrapment of rutin was proved to be efficient since no leak was observed within 30 days in concentrated MLVs phase, while 16.0 +/- 0.3% of rutin was still encapsulated after 30 days when MLVs were diluted in water. Free rutin broke up into quercetin while the encapsulated one remained stable. DPPH assay confirmed that only free and adsorbed rutin participated in antioxidant activity. (C) 2014 Elsevier Ltd. All rights reserved.

引用

页码：12 / 19

页数：8

共 37 条

[21] Design of Nano-Laminated Coatings to Control Bioavailability of Lipophilic Food Components [J].

McClements, David Julian .

JOURNAL OF FOOD SCIENCE, 2010, 75 (01) :R30-R42

[22] The spherulites™:: a promising carrier for oligonucleotide delivery [J].

Mignet, N ;

Brun, A ;

Degert, C ;

Delord, B ;

Roux, D ;

Hélène, C ;

Laversanne, R ;

François, JC .

NUCLEIC ACIDS RESEARCH, 2000, 28 (16) :3134-3142

[23] Nanostructured lipid carriers (NLC) in cosmetic dermal products [J].

Mueller, R. H. ;

Petersen, R. D. ;

Hornmoss, A. ;

Pardeike, J. .

ADVANCED DRUG DELIVERY REVIEWS, 2007, 59 (06) :522-530

[24]

Myers R., 2013, J AGR FOOD CHEM

[25] Quantitative study of the encapsulation of glucose oxidase into multilamellar vesicles and its effect on enzyme activity [J].

Olea, D ;

Faure, C .

JOURNAL OF CHEMICAL PHYSICS, 2003, 119 (12) :6111-6118

[26] Antibacterial, antifungal, and antiviral activities of some flavonoids [J].

Orhan, Didenn Deliorman ;

Ozcelik, Berrin ;

Ozgen, Selda ;

Ergun, Fatma .

MICROBIOLOGICAL RESEARCH, 2010, 165 (06) :496-504

[27] Preparation of quercetin and rutin-loaded ceramide liposomes and drug-releasing effect in liposome-in-hydrogel complex system [J].

Park, Soo Nam ;

Lee, Min Hye ;

Kim, Su Ji ;

Yu, Eun Ryeong .

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, 2013, 435 (03) :361-366

[28] FTIR, 1H NMR and EPR spectroscopy studies on the interaction of flavone apigenin with dipalmitoylphosphatidylcholine liposomes [J].

Pawlikowska-Pawlega, Bozena ;

Misiak, Lucjan E. ;

Zarzyka, Barbara ;

Paduch, Roman ;

Gawron, Antoni ;

Gruszecki, Wieslaw I. .

BIOCHIMICA ET BIOPHYSICA ACTA-BIOMEMBRANES, 2013, 1828 (02) :518-527

[29] Acute and chronic antiinflammatory effects of plant flavonoids [J].

Pelzer, LE ;

Guardia, T ;

Juarez, AO ;

Guerreiro, E .

FARMACO, 1998, 53 (06) :421-424

[30] Effect of onion-type multilamellar liposomes on Trametes versicolor laccase activity and stability [J].

Prevoteau, Antonin ;

Faure, Chrystel .

BIOCHIMIE, 2012, 94 (01) :59-65

← 1 2 3 4 →