Encapsulation of rutin and naringenin in multilamellar vesicles for optimum antioxidant activity

被引：58

作者：

Kerdudo, Audrey ^{[1
,2
]}

Dingas, Alexandre ^{[1
]}

Fernandez, Xavier ^{[2
]}

Faure, Chrystel ^{[3
]}

机构：

[1] SOFIA Cosmet, F-06514 Carros, France

[2] Univ Nice Sophia Antipolis, ICN, UMR 7272, F-06108 Nice, France

[3] Univ Bordeaux, Lab Chim & Biol Membranes & Nanoobjets, CBMN, UMR 5248, F-33600 Pessac, France

来源：

FOOD CHEMISTRY | 2014年 / 159卷

关键词：

Encapsulation; Antioxidant activity; Flavonoids; Multilamellar vesicles; GASTRO-RESISTANT MICROPARTICLES; IN-VITRO; OXIDATIVE STRESS; LIPOSOMES; FLAVONOIDS; QUERCETIN; RELEASE; STABILITY; EXTRACT; CARRIER;

D O I：

10.1016/j.foodchem.2014.03.005

中图分类号：

O69 [应用化学];

学科分类号：

081704 ;

摘要：

Rutin and naringenin, two phenolic compounds with antioxidant properties were encapsulated in lipid-based onion-type multilamellar vesicles (MLVs). After vesicles formation, the free, adsorbed/encapsulated analytes were well separated with size exclusion chromatography (SEC), and rutin and naringenin were quantified with UV-HPLC at 258 nm and 290 nm. A mathematical model was developed to separately calculate the encapsulation and the adsorption yields of both phenols. Naringenin was shown to be poorly encapsulated (<10%) but highly adsorbed on MLVs surface (>60%) whatever MLVs composition. Conversely, rutin showed high encapsulation efficiency (>60%). Entrapment of rutin was proved to be efficient since no leak was observed within 30 days in concentrated MLVs phase, while 16.0 +/- 0.3% of rutin was still encapsulated after 30 days when MLVs were diluted in water. Free rutin broke up into quercetin while the encapsulated one remained stable. DPPH assay confirmed that only free and adsorbed rutin participated in antioxidant activity. (C) 2014 Elsevier Ltd. All rights reserved.

引用

页码：12 / 19

页数：8

共 37 条

[1] Encapsulation of flavonoid in multiple emulsion using spinning disc reactor technology [J].

Akhtar, Mahmood ;

Murray, Brent S. ;

Afeisume, Ehihumeme I. ;

Khew, Shiow H. .

FOOD HYDROCOLLOIDS, 2014, 34 (01) :62-67

[2] Nanostructured Systems Containing Rutin: In Vitro Antioxidant Activity and Photostability Studies [J].

Almeida, Juliana S. ;

Lima, Fernanda ;

Da Ros, Simoni ;

Bulhoes, Luis O. S. ;

de Carvalho, Leandro M. ;

Beck, Ruy C. R. .

NANOSCALE RESEARCH LETTERS, 2010, 5 (10) :1603-1610

[3] Rate of biodistribution of STEALTH® liposomes to tumor and skin:: influence of liposome diameter and implications for toxicity and therapeutic activity [J].

Charrois, GJR ;

Allen, TM .

BIOCHIMICA ET BIOPHYSICA ACTA-BIOMEMBRANES, 2003, 1609 (01) :102-108

[4] Evaluation of antioxidant activity of aqueous extract of some selected nutraceutical herbs [J].

Chen, Hui-Yin ;

Lin, Yuh-Charn ;

Hsieh, Chiu-Lan .

FOOD CHEMISTRY, 2007, 104 (04) :1418-1424

[5] Protective effect of extract of Crataegus pinnatifida pollen on DNA damage response to oxidative stress [J].

Cheng, Ni ;

Wang, Yuan ;

Gao, Hui ;

Yuan, Jialing ;

Feng, Fan ;

Cao, Wei ;

Zheng, Jianbin .

FOOD AND CHEMICAL TOXICOLOGY, 2013, 59 :709-714

[6] Recent advances in understanding the antibacterial properties of flavonoids [J].

Cushnie, T. P. Tim ;

Lamb, Andrew J. .

INTERNATIONAL JOURNAL OF ANTIMICROBIAL AGENTS, 2011, 38 (02) :99-107

[7] Characterization and in vitro evaluation of spherulites as sequestering vesicles with potential application in drug detoxification [J].

Dhanikula, Anand Babu ;

Lafleur, Michel ;

Leroux, Jean-Christophe .

BIOCHIMICA ET BIOPHYSICA ACTA-BIOMEMBRANES, 2006, 1758 (11) :1787-1796

[8]

DIAT O, 1993, J PHYS II, V3, P9, DOI 10.1051/jp2:1993106

[9] Magnetic Multilamellar Liposomes Produced by In Situ Synthesis of Iron Oxide Nanoparticles: "Magnetonions" [J].

Faure, Chrystel ;

Meyre, Marie-Edith ;

Trepout, Sylvain ;

Lambert, Olivier ;

Lebraud, Eric .

JOURNAL OF PHYSICAL CHEMISTRY B, 2009, 113 (25) :8552-8559

[10]

Fernandez X., 2012, CONSERVATEURS COSMET

← 1 2 3 4 →